Longitudinal Study Investigating the Relationship between Disease Activity and Psychological Status of Patients with Behçet's Disease.

PURPOSE: To compare longitudinal changes in disease activity with quality of life and psychological status in patients with Behçet's disease (BD). METHODS: Patients attending a National Centre of Excellence for BD over a two-year period had disease activity including clinician and patient perception of disease documented and completed a number of validated quality of life and psychological questionnaires. Some representative case-studies were examined in detail. RESULTS: 102 patients were included. Disease activity weakly correlated with quality of life and psychological health. Clinician and patient perceptions strongly correlated with each other. Case-study analyses showed diverse, and sometimes incongruous, responses between, and in, individual patients. CONCLUSION: Changes in disease activity account for only a small proportion of changes in psychological status with intra-individual variation playing a large role. There is a complex relationship between psychological status and disease activity that cannot be explained by changes in disease activity alone.

Effectiveness And Acceptability Of Ready-To-Use Therapuetic Foods Among Malnourished Children In A Tertiary Care Hospital.

BACKGROUND: Ready-to-use-therapeutic foods (RUTF) are an important component of the effective outpatient treatment of severe wasting because most of the child deaths in the world especially in developing countries is due to malnutrition. The objective of the study was to evaluate the effectiveness and acceptability of ready to use therapeutic food among malnourished children in a tertiary care hospital. METHODS: An observational exploratory study based on sixty subjects with 3-120 months of age, malnourished children were chosen by universal sampling from Children Hospital Lahore, Pakistan, during the time period 1st September 2012 to 30th November 2012 with the approval of ethical committee. The study tool for investigation was a well-structured questionnaire. RESULTS: The highest proportion of malnourished children belonged to urban areas (71.67%) and age group <24 months (65%).The effect of RUTF on weight for height and weight for age Z score from baseline to the end of follow-up was statistically significant (Paired sample t-test) (p=0.000, 0.000) but there was no significant effect of RUTF on height for age (p-value=0.14).The acceptance of food among patients was good, the proportion of patient was higher who consumed ready to use therapeutic food easily (70%), percentage of vomiting (16.7%) and complaints of diarrhoea (46.7%) after taking RUTF was less in patients. All mothers were satisfied from ready to use therapeutic foods (100%). CONCLUSIONS: Malnourished children gained weight after the short term supplementation of ready to use therapeutic food but had no significant effect on height of the patients. Its acceptability in term of taste, amount consumes and demand was good. Mother's perception was also satisfactory regarding these foods.

Structural, magnetic and electronic structure studies of NdFe(1-x)Ni(x)O(3) (0 ≤ x ≤ 0.3).

We present here the structural, electronic structure, magnetic and Mössbauer studies of NdFe(1-x)Ni(x)O(3) (0≤x≤0.3) samples. All the samples exhibit a single-phase orthorhombic structure with space group Pbnm. The near-edge x-ray absorption fine structure (NEXAFS) studies reveal that, with the Ni substitution at Fe sites, a new spectral feature about 1.5 eV lower than the pre-edge structure of NdFeO(3) in the O K edge is observed due to the 3d contraction effect and is growing monotonically with the increase of Ni concentration. The Fe L(3,2), Ni L(3,2) and Nd M(5,4) edges confirm the trivalent state of Fe, Ni and Nd ions. The Mössbauer spectra fitted with two Zeeman sextets confirm the different surroundings of Ni around Fe ions. With the increase in Ni concentration, the sextets are broadened. The increase of quadrupole splitting and the decrease of the hyperfine field suggest the change in the ordered regime of the system. The magnetic behaviour at low temperatures is explained in the context of competition among moments of rare earth (Nd) and transition metal ions (Fe/Ni). The strong paramagnetic contribution of the Nd magnetic sublattice and spin flip phenomenon is observed from the temperature dependence of zero-field-cooled and field-cooled magnetization where spin crossover is observed. The isothermal hysteresis loops show a decrease of magnetization and increase of coercivity with the increase in temperature and complements magnetization versus temperature. The results are explained on the basis of the spin reorientation phenomenon.