RESUMO
AIM: This study investigated the haematinic, antihyperlipidaemic, hepato-renal protective effects of Terminalia catappa aqueous leaf extract on male Wistar rats exposed to phenylhydrazine toxicity. METHODS: Animals were exposed to phenylhydrazine (PHZ) 50 mg/kg intraperitoneal for two consecutive days thereafter, treated with T. catappa extract (100 mg/kg and 200 mg/kg) orally for 21 days. After the experimentation, animals were sedated with ketamine (70 mg/kg) and euthanized by cervical dislodgement. Blood and organs were collected for haematology and biochemical studies following standard laboratory methods. RESULTS: Our study showed that T. catappa significantly increased erythrocytes, haemoglobin, haematocrit and high density lipoprotein as well as down-regulating leukocytes, thrombocytes, ALP AST, ALT creatinine, urea, total cholesterol as well as low density lipoprotein. The liver, kidney and spleen antioxidant defence were also up-regulated against the adverse effect caused by phenylhydrazine exposure. CONCLUSION: Terminalia catappa attenuated Phenylhydrazine-induced anaemia and hepato-renal toxicity in male Wistar rat by boosting blood cells, modulation of lipoproteins and up-regulation of in vivo antioxidant armouries.
Assuntos
Anemia , Terminalia , Ratos , Masculino , Animais , Antioxidantes/farmacologia , Ratos Wistar , Extratos Vegetais/farmacologia , Regulação para Cima , Fígado , Células Sanguíneas , Lipoproteínas/farmacologiaRESUMO
The effect of ethanol extract of Carpolobia lutea leaves on experimentally induced diarrhoea and ulcers was studied in rodents. The extract (245-735 mg/kg) inhibited small intestinal transit time (15.10-45.03%), castor oil-induced diarrhoea (25.69-43.54%) and fluid accumulation (7.53-34.15%), respectively, as well as indomethancin (47.64-79.79%) and ethanol-induced (65.63-89.65%) ulcer models. The various degrees of inhibitions were statistically significant (p < 0.001). The phytochemical screening confirmed the presence of tannins, saponins and flavonoids. Others include cardiac glycosides, anthraquinones and terpenes. The median lethal dose (LD50) was determined to be 2449.49 mg/kg body weight. Though the mechanism of action of the extract may not be fully understood, the extract may in part be mediating its actions through its inhibitory effects on alpha2-adrenoceptor and cholinergic (anti-muscarinic receptor) systems or through the actions of its active metabolites.