[Passive microhemagglutination reaction to Treponema pallidum in the cerebrospinal fluid in the diagnosis of neurosyphilis]. / Contribuição da reação de micro-hemaglutinação passiva para o treponema pallidum (mha-tp) no líquido cefalorraqueano ao diagnóstico de neurossífilis.

A quantitative micro-hemagglutination test for antibodies to Treponema pallidum (MHA-TP) was evaluated in 25 cerebrospinal fluid (CSF) samples obtained from patients with neurosyphilis (NS group) and in 7 CSF samples of patients with reactive serologic tests for syphilis (STS+). These data were compared to treponemal and nontreponemal tests. The MHA-TP was reactive in all of the 25 NS group samples, the FTA-Abs and the complement fixation of Wassermann (CFW) were in 24 and the VDRL in only 9. In the 7 STS+ samples (STS+ group), the MHA-TP was reactive in 6, the FTA-Abs in all of them and the nontreponemal tests were nonreactive. Results analyses support conclusion the clinical diagnosis of NS must be complemented by cytoproteic dual and immunological treponemal and nontreponemal assays in CSF. The MHA-TP test was as sensitive as FTA-Abs and required less technical and interpretative skills, contributing in association to CFW to NS diagnosis.

[Cerebrospinal fluid changes in multiple myeloma. Review of the literature and report of a case]. / Alterações do liquido cefalorraqueano no mieloma multiplo. Revisão de literatura e registro de um caso.

The authors make a literature review about the meningeal involvement in MM and verified that the presence of myeloma cells in the CSF is rare. They report a case of cranial MM in which the atypical plasma cells (plasmoblasts) were present in CSF. The CSF examination was the principal finding to the diagnosis of this case; it was confirmed by IgG monoclonal "M" gamophaty present in serum, CSF and urine obtained through proteic electrophoresis profile and by necropsy that revealed mielomatous proliferation in skull base with subarachnoidal space infiltration.

Alteracoes do liquido cefalorraqueano no mieloma multiplo: revisao de literatura e registro de um caso. / Changes in the cerebrospinal fluid in multiple myeloma: review of the literature and report of a case

Os autores fazem uma revisao de literatura sobre o comprometimento do sistema nervoso central em casos de mieloma multiplo (MM) verificando que o aparecimento de celulas plasmaticas atipicas (plasmoblastos) no LCR e raro. E apresentado um caso MM tipo IgG de localizacao predominantemente nos ossos das base do cranio. O exame do LCR foi um dos principais para o diagnostico da neoplasia, cuja citomorfologia revelou exclusivamente a presenca de plasmoblastos. A confirmacao do diagnostico se fez pelo perfil eletroforetico das proteinas do soro, do LCR e da urina, que revelou uma gamopatia monoclonal "M" tipo IgG e, tambem pelos achados de necropsia que evidenciaramm proliferacao mielomatosa nos ossos da base do cranio com infiltracao do espaco subaracnoideo craniano

Determinacao da lisozima no liquido cefalorraqueano normal e patologico. / Determination of lisozymes in the normal and pathological cerebrospinal fluid

As concentracoes da LZM foram determinadas nas amostras de LCR normal e patologico; o metodo utilizado foi o turbidimetrico melhorado. A LZM foi mensuravel em todas as amostras normais; apresentou-se aumentada em 60% e 83% dos casos de meningites virais e bacterianas, respectivamente. Foram, tambem observadas elevacoes em neurocisticercose, leucemia linfoblastica aguda, mieloma multiplo e neurocriptococose, nos dois casos de neurolues, a LZM do LCR foi normal

Infeccoes graves em recem-nascidos por bacterias do trato genital. / Severe infections in newborn infants due to bacteria of genital tract

Sao descritos dois casos de meningite bacteriana causada por Streptococcus sp tipo B-hemolitico do grupo B de Lancefield em recemnascidos. Sao discutidos aspectos clinicos, diagnostico laboratorial e etiologia