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1.
Bull Med Libr Assoc ; 83(1): 22-6, 1995 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-7703934

RESUMO

Librarians are being urged to conduct research as one of their professional responsibilities. Many librarians, however, avoid research, because they believe it is beyond their capabilities or resources. This paper discusses the importance of conducting applied research-research directed toward solving practical problems. The paper describes how one library conducted practical research projects, including use studies and surveys, over an eighteen-year period. These projects produced objective data that were used by the library to make management decisions that benefited both the library and its parent institution. This paper encourages other librarians to conduct practical research projects and to share the results with their colleagues through publication in the professional literature.


Assuntos
Bibliotecários , Bibliotecas Médicas , Pesquisa , Coleta de Dados , Entrevistas como Assunto , Bibliotecas Médicas/organização & administração , Levantamentos de Bibliotecas , Inquéritos e Questionários
4.
J Biol Chem ; 263(2): 902-10, 1988 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-2826467

RESUMO

The SP6 polymerase/promoter system was used to synthesize porcine pro-opiomelanocortin mRNAs with nucleotide sequence deletions in the 5'- as well as 3'-untranslated and coding regions. The translational efficiency of the mutant mRNAs was evaluated by cell-free translation or by monitoring the rate and extent of ribosome binding in the presence of sparsomycin. The results of these experiments indicate that specific nucleotide sequences in the 5'-untranslated and coding regions of the pro-opiomelanocortin mRNA decrease its rate of translation. Structure mapping of the mRNA with double-strand and single-strand specific nucleases suggests that these sequences can form stable secondary structures.


Assuntos
Proteínas de Bactérias , Desoxirribonucleases de Sítio Específico do Tipo II , Pró-Opiomelanocortina/genética , Biossíntese de Proteínas , RNA Mensageiro/metabolismo , Animais , Deleção Cromossômica , Enzimas de Restrição do DNA/metabolismo , Eletroforese em Gel de Poliacrilamida , Conformação de Ácido Nucleico , Ribonuclease T1/metabolismo , Ribossomos/metabolismo , Suínos
5.
Bull Med Libr Assoc ; 68(4): 357-66, 1980 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-7437589

RESUMO

In order to determine the content of a journal collection responsive to both user needs and space and dollar constraints, quantitative measures of the use of a 647-title collection have been related to space and cost requirements to develop objective criteria for a dynamic collection for the Treadwell Library at the Massachusetts General Hospital, a large medical research center. Data were collected for one calendar year (1977) and stored with the elements for each title's profile in a computerized file. To account for the effect of the bulk of the journal runs on the number of uses, raw use data have been adjusted using linear shelf space required for each title to produce a factor called density of use. Titles have been ranked by raw use and by density of use with space and cost requirements for each. Data have also been analyzed for five special categories of use. Given automated means of collecting and storing data, use measures should be collected continuously. Using raw use frequency ranking to relate use to space and costs seems sensible since a decision point cutoff can be chosen in terms of the potential interlibrary loans generated. But it places new titles at risk while protecting titles with long, little used runs. Basing decisions on density of use frequency ranking seems to produce a larger yield of titles with fewer potential interlibrary loans and to identify titles with overlong runs which may be pruned or converted to microform. The method developed is simple and practical. Its design will be improved to apply to data collected in 1980 for a continuous study of journal use. The problem addressed is essentially one of inventory control. Viewed as such it makes good financial sense to measure use as part of the routine operation of the library to provide information for effective management decisions.


Assuntos
Serviços de Informação/organização & administração , Bibliotecas Hospitalares/organização & administração , Publicações Periódicas como Assunto , Humanos , Bibliotecas Hospitalares/economia , Bibliotecas Hospitalares/estatística & dados numéricos , Massachusetts , Publicações Periódicas como Assunto/economia
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