RESUMO
The idea of cerebrovascular injury in cases of thromboangiitis obliterans was not strange to Leo Buerger, but Jäger (1932), as well Lindenberg and Spatz (1939), first established it. The aim of this study was to investigate the hemodynamics in the basal cerebral arteries by means of transcranial Doppler in patients with thromboangiitis obliterans. Thirty patients (all men; average age 40.03 +/- 16.4 years) were included--one group twenty-four to forty years of age and another group forty-one to fifty years of age. The results show that the blood flow velocities in middle and anterior cerebral arteries in both groups of patients were significantly lower than in healthy persons. The trends towards reduction of blood flow velocity were also evident in posterior cerebral arteries. The authors describe in detail 2 patients who suffered major ischemic stroke. Cerebrovascular disorders in Buerger's disease are probably more frequent than supposed and have to be taken into account.
Assuntos
Transtornos Cerebrovasculares/diagnóstico por imagem , Tromboangiite Obliterante/diagnóstico por imagem , Ultrassonografia Doppler Transcraniana , Adulto , Velocidade do Fluxo Sanguíneo , Isquemia Encefálica/diagnóstico por imagem , Isquemia Encefálica/fisiopatologia , Artérias Cerebrais/diagnóstico por imagem , Artérias Cerebrais/fisiopatologia , Circulação Cerebrovascular , Transtornos Cerebrovasculares/fisiopatologia , Hemodinâmica , Humanos , Masculino , Pessoa de Meia-Idade , Sístole , Tromboangiite Obliterante/fisiopatologiaAssuntos
Coagulação Intravascular Disseminada/fisiopatologia , Trombose/fisiopatologia , Adolescente , Criança , Pré-Escolar , Coagulação Intravascular Disseminada/tratamento farmacológico , Quimioterapia Combinada , Heparina/uso terapêutico , Humanos , Estreptoquinase/uso terapêutico , Trombose/tratamento farmacológicoRESUMO
Systemic application of streptokinase in fibrinolytic therapy of acute myocardial infarction was reported and the advantages over intracoronary application were discussed.
Assuntos
Fibrinólise , Heparina/uso terapêutico , Infarto do Miocárdio/tratamento farmacológico , Estreptoquinase/uso terapêutico , Idoso , Anticoagulantes/uso terapêutico , Feminino , Heparina/administração & dosagem , Humanos , Infusões Parenterais , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/sangue , Estreptoquinase/administração & dosagemRESUMO
In 62% of the cases with Fallot's complex disturbances of haemostasis were found. Their pathogenesis is assumed to be a complex one: On the one hand, chronic consumption coagulopathy may play a role; on the other hand, impairment of the RES function or inhibition of haemostasis and disturbances of thrombocytopoesis due to hypoxia have to be taken into consideration.
Assuntos
Testes de Coagulação Sanguínea , Hemostasia , Tetralogia de Fallot/sangue , Adolescente , Transfusão de Sangue , Criança , Pré-Escolar , Contagem de Eritrócitos , Insuficiência Cardíaca/sangue , Hematócrito , Hemodiluição , Hemoglobinometria , Hemostasia/efeitos dos fármacos , Heparina/uso terapêutico , Humanos , Lactente , Oxigênio/sangue , Tempo de Tromboplastina Parcial , Contagem de PlaquetasRESUMO
Fibrinolytic treatment during the early post-operative period is associated with a real danger of hemorrhage. On the other hand, in palliative shunt procedures in Fallot's disease, especially in small children, the anastomoses may thrombose. In such cases the therapeutic lysis of the thrombus improves the child's condition and may defer further surgery. The authors describe five cases of children with Fallot's disease and thrombosis of Blalock-Taussig anastomoses who were successfully treated by streptokinase. They conclude that fibrinolytic treatment should be considered in early thrombosis following anastomosing operations.
