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1.
bioRxiv ; 2024 Apr 22.
Artigo em Inglês | MEDLINE | ID: mdl-38712193

RESUMO

A remarkable demonstration of the flexibility of mammalian motor systems is primates' ability to learn to control brain-computer interfaces (BCIs). This constitutes a completely novel motor behavior, yet primates are capable of learning to control BCIs under a wide range of conditions. BCIs with carefully calibrated decoders, for example, can be learned with only minutes to hours of practice. With a few weeks of practice, even BCIs with randomly constructed decoders can be learned. What are the biological substrates of this learning process? Here, we develop a theory based on a re-aiming strategy, whereby learning operates within a low-dimensional subspace of task-relevant inputs driving the local population of recorded neurons. Through comprehensive numerical and formal analysis, we demonstrate that this theory can provide a unifying explanation for disparate phenomena previously reported in three different BCI learning tasks, and we derive a novel experimental prediction that we verify with previously published data. By explicitly modeling the underlying neural circuitry, the theory reveals an interpretation of these phenomena in terms of biological constraints on neural activity.

2.
Braz J Med Biol Res ; 53(6): e9113, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32401924

RESUMO

Chemerin is an adipokine that has been associated with components of metabolic syndrome. It has been described to affect adipocyte metabolism and inflammatory responses in adipose tissue, as well as the systemic metabolism of lipids and glucose. Few epidemiological studies have evaluated classical and genetics cardiovascular risk factors (CVRFs) in the mixed adult rural population in Brazil. Therefore, the present study explored possible associations between CVRFs and chemerin. This cross-sectional study included 508 adults from the rural localities of Lavras Novas, Chapada, and Santo Antônio do Salto in Ouro Preto, Minas Gerais, Southeast Brazil. Demographic, behavioral, clinical, biochemical, anthropometric variables, and 12 single nucleotide polymorphisms (SNPs) linked with metabolic syndrome phenotypes were evaluated for associations with chemerin level. There was a significant association of high triglyceride levels [odds ratio (OR)=1.91, 95%CI: 1.23-2.98], insulin resistance (OR=1.82, 95%CI: 1.03-3.22), age (OR=1.64, 95%CI: 1.08-2.49), and sex (OR=1.99, 95%CI: 1.35-2.95) with high levels of chemerin. High chemerin levels were significantly associated with the genetic polymorphisms rs693 in the APOB gene (OR=1.50, 95%CI: 1.03-2.19) and rs1799983 in the NOS3 gene (OR=1.46, 95%CI: 1.01-2.12) for the AA and GT+TT genotypes, respectively. In the concomitant presence of genotypes AA of rs693 and GT+TT of rs1799983, the chance of presenting high levels of chemerin showed a 2.21-fold increase (95%CI: 1.25-3.88) compared to the reference genotype. The development of classical CVRFs in this population may be influenced by chemerin and by two risk genotypes characteristic of variants in well-studied genes for hypertension and dyslipidemia.


Assuntos
Apolipoproteínas B/genética , Doenças Cardiovasculares/genética , Quimiocinas/sangue , Óxido Nítrico Sintase Tipo III/genética , Polimorfismo de Nucleotídeo Único/genética , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Brasil , Doenças Cardiovasculares/metabolismo , Quimiocinas/genética , Estudos Transversais , Feminino , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , População Rural , Adulto Jovem
3.
Braz. j. med. biol. res ; 53(6): e9113, 2020. tab, graf
Artigo em Inglês | LILACS, Coleciona SUS | ID: biblio-1132518

RESUMO

Chemerin is an adipokine that has been associated with components of metabolic syndrome. It has been described to affect adipocyte metabolism and inflammatory responses in adipose tissue, as well as the systemic metabolism of lipids and glucose. Few epidemiological studies have evaluated classical and genetics cardiovascular risk factors (CVRFs) in the mixed adult rural population in Brazil. Therefore, the present study explored possible associations between CVRFs and chemerin. This cross-sectional study included 508 adults from the rural localities of Lavras Novas, Chapada, and Santo Antônio do Salto in Ouro Preto, Minas Gerais, Southeast Brazil. Demographic, behavioral, clinical, biochemical, anthropometric variables, and 12 single nucleotide polymorphisms (SNPs) linked with metabolic syndrome phenotypes were evaluated for associations with chemerin level. There was a significant association of high triglyceride levels [odds ratio (OR)=1.91, 95%CI: 1.23−2.98], insulin resistance (OR=1.82, 95%CI: 1.03−3.22), age (OR=1.64, 95%CI: 1.08−2.49), and sex (OR=1.99, 95%CI: 1.35−2.95) with high levels of chemerin. High chemerin levels were significantly associated with the genetic polymorphisms rs693 in the APOB gene (OR=1.50, 95%CI: 1.03−2.19) and rs1799983 in the NOS3 gene (OR=1.46, 95%CI: 1.01−2.12) for the AA and GT+TT genotypes, respectively. In the concomitant presence of genotypes AA of rs693 and GT+TT of rs1799983, the chance of presenting high levels of chemerin showed a 2.21-fold increase (95%CI: 1.25−3.88) compared to the reference genotype. The development of classical CVRFs in this population may be influenced by chemerin and by two risk genotypes characteristic of variants in well-studied genes for hypertension and dyslipidemia.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Adulto Jovem , Apolipoproteínas B/genética , Doenças Cardiovasculares/genética , Quimiocinas/sangue , Polimorfismo de Nucleotídeo Único/genética , Óxido Nítrico Sintase Tipo III/genética , População Rural , Brasil , Doenças Cardiovasculares/metabolismo , Estudos Transversais , Fatores de Risco , Quimiocinas/genética , Genótipo
4.
J Neural Eng ; 12(1): 016015, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25605498

RESUMO

OBJECTIVE: Brain-computer interfaces (BCIs) are being developed to assist paralyzed people and amputees by translating neural activity into movements of a computer cursor or prosthetic limb. Here we introduce a novel BCI task paradigm, intended to help accelerate improvements to BCI systems. Through this task, we can push the performance limits of BCI systems, we can quantify more accurately how well a BCI system captures the user's intent, and we can increase the richness of the BCI movement repertoire. APPROACH: We have implemented an instructed path task, wherein the user must drive a cursor along a visible path. The instructed path task provides a versatile framework to increase the difficulty of the task and thereby push the limits of performance. Relative to traditional point-to-point tasks, the instructed path task allows more thorough analysis of decoding performance and greater richness of movement kinematics. MAIN RESULTS: We demonstrate that monkeys are able to perform the instructed path task in a closed-loop BCI setting. We further investigate how the performance under BCI control compares to native arm control, whether users can decrease their movement variability in the face of a more demanding task, and how the kinematic richness is enhanced in this task. SIGNIFICANCE: The use of the instructed path task has the potential to accelerate the development of BCI systems and their clinical translation.


Assuntos
Interfaces Cérebro-Computador , Eletroencefalografia/métodos , Potencial Evocado Motor/fisiologia , Córtex Motor/fisiologia , Movimento/fisiologia , Desempenho Psicomotor/fisiologia , Animais , Periféricos de Computador , Sinais (Psicologia) , Macaca mulatta , Masculino , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
5.
Bioresour Technol ; 135: 128-36, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23265815

RESUMO

The microalga Nannochloropsis sp. was used in this study, in a biorefinery context, as biomass feedstock for the production of fatty acids for biodiesel, biohydrogen and high added-value compounds. The microalgal biomass, which has a high lipid and pigment content (mainly carotenoids), was submitted to supercritical CO2 extraction. The temperature, pressure and solvent flow-rate were evaluated to check their effect on the extraction yield. The best operational conditions to extract 33 g lipids/100 g dry biomass were found to be at 40 °C, 300 bar and a CO2 flow-rate of 0.62 g/min. The effect of adding a co-solvent (ethanol) was also studied. When supercritical CO2 doped with 20% (w/w) ethanol was used, it was possible to extract 45 g lipids/100 g dry biomass of lipids and recover 70% of the pigments. Furthermore, the remaining biomass after extraction was effectively used as feedstock to produce biohydrogen through dark fermentation by Enterobacter aerogenes resulting in a hydrogen production yield of 60.6 mL/g dry biomass.


Assuntos
Biocombustíveis/microbiologia , Biomassa , Biotecnologia/métodos , Hidrogênio/metabolismo , Microalgas/metabolismo , Óleos/isolamento & purificação , Pigmentos Biológicos/isolamento & purificação , Cromatografia Líquida de Alta Pressão , Cromatografia com Fluido Supercrítico , Fermentação , Lipídeos/análise , Solventes/química
6.
J Hazard Mater ; 163(2-3): 517-23, 2009 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-18722053

RESUMO

The physicochemical characteristics of three Brazilian peats were investigated using elemental analysis, scanning electron microscopy (SEM), X-ray diffractometry (XRD) and studies of Cr(III) biosorption based on adsorption isotherms. Adsorption of Cr(III) by in natura peat from Santo Amaro das Brotas (Sergipe State) was much greater than by peats from either Ribeirão Preto (São Paulo State) or Itabaiana (Sergipe State), with adsorption capacities (q) of 4.90+/-0.01, 1.70+/-0.01 and 1.40+/-0.01 mg g(-1), respectively. Pre-treatments with HCl and NaOH+HCl reduced adsorption by the Santo Amaro das Brotas peat, showing that adsorption efficiency was associated with the amount of organic matter present. Conversely, increase in the mineral content following pre-treatment increased adsorption of Cr(III) by the Ribeirão Preto and Itabaiana peats. Highest adsorption (retention >95.0%) was achieved at equilibrium pH 4.0 using the Santo Amaro das Brotas peat. Experimental data for the adsorption of Cr(III) from aqueous solution onto this peat were fitted to the Langmuir equation, from which an equilibrium adsorption capacity, q(max), of 5.60 mg g(-1) was obtained, which was close to the experimentally determined value.


Assuntos
Cromo/isolamento & purificação , Solo/normas , Poluentes Químicos da Água/isolamento & purificação , Adsorção , Resíduos Industriais , Purificação da Água/métodos
7.
Exp Brain Res ; 153(2): 134-9, 2003 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-14610632

RESUMO

In the lateral intraparietal area (LIP), a saccade-related region of the posterior parietal cortex (PPC), spiking activity recorded during the memory period of an instructed-delay task exhibits temporal structure that is spatially tuned. These results provide evidence for the existence of 'dynamic memory fields' which can be read-out by other brain areas, along with information contained in the mean firing rate, to give the direction of a planned movement. We looked for evidence of dynamic memory fields in spiking activity in two parietal reach areas, the parietal reach region (PRR) and area 5. Monkeys made center-out reaches to eight target locations in an instructed-delay task with a memory component. Neurons in both areas exhibited sustained activity during the delay period that was spatially tuned. Many single cell PRR spectra exhibited spatially tuned temporal structure, as evidenced by a significant and spatially tuned peak in the 20-50 Hz band. The PRR population spectrum of spike trains was also tuned, with the peak power centered on approximately 25 Hz. In contrast, area 5 spiking activity did not exhibit any significant temporal structure. These results suggest that different mechanisms underlie sustained delay period activity in these two areas and that dynamic memory fields, as revealed by our techniques, are more prominent in PRR than in area 5. Temporal structure in the spike train and local field potential (LFP) are related in at least one other brain area (LIP). The present results suggest then that LFP activity obtained from PRR may be better suited than area 5 LFP activity for use in neural prosthetic systems that incorporate analysis of temporal structure as part of a decode mechanism for extracting intended movement goals.


Assuntos
Potenciais de Ação/fisiologia , Movimento/fisiologia , Lobo Parietal/fisiologia , Desempenho Psicomotor/fisiologia , Percepção Espacial/fisiologia , Animais , Braço/fisiologia , Macaca mulatta , Memória/fisiologia , Neurônios/fisiologia , Lobo Parietal/citologia
8.
J Neurophysiol ; 85(2): 539-44, 2001 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-11160491

RESUMO

Distinct subregions of the posterior parietal cortex contribute to planning different movements. The parietal reach region (PRR) is active during the delay period of a memory-guided reach task but generally not active during a memory-guided saccade task. We explored whether the reach planning activity in PRR is related to remembering targets for reaches or if it is related to specifying the reach that the monkey is about to perform. Monkeys were required to remember two target locations and then reach to them in sequence. Before the movements were executed, PRR neurons predominantly represented the reach about to be performed and only rarely represented the remembered target for the second reach. This indicates the area plays a role in specifying the target for the impending reach and may not contribute to storing the memory of subsequent reach targets.


Assuntos
Membro Anterior/fisiologia , Movimento/fisiologia , Lobo Parietal/fisiologia , Desempenho Psicomotor/fisiologia , Animais , Macaca mulatta , Masculino , Memória/fisiologia
9.
Vision Res ; 40(10-12): 1433-41, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10788650

RESUMO

Over the last few years it is becoming increasingly apparent that an important role of the posterior parietal cortex is to process sensory information for the purpose of planning actions. We review studies showing that a large component of neural activity in area LIP is related to planning saccades and activity in a nearby parietal reach region (PRR) to reaches. This intention related activity dominates the delay period in delayed movement tasks, and also comprises a substantial component of the transient response. These findings, along with additional anatomical and physiological evidence, lends support to the idea that different cortical areas within the PPC represent plans for different actions. We also found strong modulation of activity when movement plans were changed without changes in the locus of attention. This result suggests that PPC, which has been postulated to play a role in shifting attention, may also play a role in changing movement intentions. Sensory related activity was also present in these tasks and may be related to the stimulus or to attention. These experiments show that there are intention and sensory related activities in the PPC consistent with its proposed role in sensory-motor transformations. These studies also show that care must be taken to measure intention-related signals and not assume that all task dependent modulation in the PPC reflects attention.


Assuntos
Lobo Parietal/fisiologia , Movimentos Sacádicos/fisiologia , Sensação/fisiologia , Movimento/fisiologia
10.
Curr Biol ; 10(4): R145-8, 2000 Feb 24.
Artigo em Inglês | MEDLINE | ID: mdl-10704408

RESUMO

Sensory information is acquired in spatial coordinate systems linked to sense organs, yet movement must be executed in coordinate systems linked to motor effector organs. Neurophysiological experiments are yielding new insights into how the brain transforms coordinate systems to facilitate movement.


Assuntos
Encéfalo/fisiologia , Desempenho Psicomotor/fisiologia , Animais , Humanos , Neurônios/fisiologia , Córtex Visual/fisiologia
11.
J Neurophysiol ; 83(2): 1099-102, 2000 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-10669521

RESUMO

In previous experiments, we showed that cells in the parietal reach region (PRR) in monkey posterior parietal cortex code intended reaching movements in an eye-centered frame of reference. These cells are more active when an arm compared with an eye movement is being planned. Despite this clear preference for arm movements, we now report that PRR neurons also fire around the time of a saccade. Of 206 cells tested, 29% had perisaccadic activity in a delayed-saccade task. Two findings indicate that saccade-related activity does not reflect saccade planning or execution. First, activity is often peri- or postsaccadic but seldom presaccadic. Second, cells with saccade-related activity were no more likely to show strong saccadic delay period activity than cells without saccade-related activity. These findings indicate that PRR cells do not take part in saccade planning. Instead, the saccade-related activity in PRR may reflect cross-coupling between reach and saccade pathways that may be used to facilitate eye-hand coordination. Alternatively, saccade-related activity may reflect eye position information that could be used to maintain an eye-centered representation of intended reach targets across eye movements.


Assuntos
Lobo Parietal/fisiologia , Desempenho Psicomotor/fisiologia , Movimentos Sacádicos/fisiologia , Animais , Braço/fisiologia , Macaca mulatta , Movimento/fisiologia , Tempo de Reação/fisiologia
12.
Science ; 285(5425): 257-60, 1999 Jul 09.
Artigo em Inglês | MEDLINE | ID: mdl-10398603

RESUMO

The neural events associated with visually guided reaching begin with an image on the retina and end with impulses to the muscles. In between, a reaching plan is formed. This plan could be in the coordinates of the arm, specifying the direction and amplitude of the movement, or it could be in the coordinates of the eye because visual information is initially gathered in this reference frame. In a reach-planning area of the posterior parietal cortex, neural activity was found to be more consistent with an eye-centered than an arm-centered coding of reach targets. Coding of arm movements in an eye-centered reference frame is advantageous because obstacles that affect planning as well as errors in reaching are registered in this reference frame. Also, eye movements are planned in eye coordinates, and the use of similar coordinates for reaching may facilitate hand-eye coordination.


Assuntos
Atividade Motora , Neurônios/fisiologia , Lobo Parietal/fisiologia , Desempenho Psicomotor , Percepção Visual/fisiologia , Animais , Braço/fisiologia , Fixação Ocular , Macaca mulatta , Córtex Motor/fisiologia , Vias Neurais/fisiologia , Neurônios Aferentes/fisiologia , Movimentos Sacádicos , Vias Visuais/fisiologia
13.
Eur J Dermatol ; 8(5): 355-6, 1998.
Artigo em Inglês | MEDLINE | ID: mdl-9683871

RESUMO

Camptodactyly is a permanent flexion deformity at the interphalangeal joints, usually at the proximal, interphalangeal joints. It is by far most commonly encountered in the little finger, but it can occur in any of the others, and may be associated with a deformity in the little finger or not. It is usually bilateral. It can also appear in the toes, the second toe being the most frequently affected. This deformity can appear in two different situations: it can occur in isolation, or can be a part of a malformative syndrome. It can also be sporadic or be transmitted as an autosomal dominant trait [1, 5, 7, 8]. We report a case of familial camptodactyly not associated with any other disorders: the differential diagnoses included scleroderma and Dupuytren's contracture.


Assuntos
Contratura/genética , Articulações dos Dedos , Articulação do Dedo do Pé , Criança , Feminino , Humanos , Linhagem
14.
J Neurophysiol ; 79(5): 2814-9, 1998 May.
Artigo em Inglês | MEDLINE | ID: mdl-9582248

RESUMO

The lateral intraparietal area (LIP) of macaque monkey, and a parietal reach region (PRR) medial and posterior to LIP, code the intention to make visually guided eye and arm movements, respectively. We studied the effect of changing the motor plan, without changing the locus of attention, on single neurons in these two areas. A central target was fixated while one or two sequential flashes occurred in the periphery. The first appeared either within the response field of the neuron being recorded or else on the opposite side of the fixation point. Animals planned a saccade (red flash) or reach (green flash) to the flash location. In some trials, a second flash 750 ms later could change the motor plan but never shifted attention: second flashes always occurred at the same location as the preceding first flash. Responses in LIP were larger when a saccade was instructed (n = 20 cells), whereas responses in PRR were larger when a reach was instructed (n = 17). This motor preference was observed for both first flashes and second flashes. In addition, the response to a second flash depended on whether it affirmed or countermanded the first flash; second flash responses were diminished only in the former case. Control experiments indicated that this differential effect was not due to stimulus novelty. These findings support a role for posterior parietal cortex in coding specific motor intention and are consistent with a possible role in the nonspatial shifting of motor intention.


Assuntos
Atenção/fisiologia , Processos Mentais/fisiologia , Lobo Parietal/fisiologia , Desempenho Psicomotor/fisiologia , Animais , Macaca mulatta , Masculino , Neurônios/fisiologia , Estimulação Luminosa , Movimentos Sacádicos/fisiologia
15.
Novartis Found Symp ; 218: 109-22; discussion 122-8, 171-5, 1998.
Artigo em Inglês | MEDLINE | ID: mdl-9949818

RESUMO

The posterior parietal cortex (PPC) has long been considered a sensory area specialized for spatial awareness and the directing of attention. However, a new, far reaching concept is now emerging that this area is involved in integrating sensory information for the purpose of planning action. Moreover, experiments by our group and others over the last two decades indicate that PPC is in fact anatomically organized with respect to action. PPC also is an 'association' cortex which must combine different sensory modalities which are coded in different coordinate frames. We have found, at least for two different cortical areas within PPC, that different sensory signals are brought into a common coordinate frame. This coordinate frame codes locations with respect to the eye, but also gain modulates the activity by eye and body position signals. An interesting feature of this coordinate representation at the population level is that it codes concurrently target locations in multiple coordinate frames (eye, head, body and world). Depending on how this population of neurons is sampled, different coordinate transformations can be accomplished by the same population of neurons.


Assuntos
Movimentos Oculares/fisiologia , Força da Mão/fisiologia , Lobo Parietal/fisiologia , Desempenho Psicomotor/fisiologia , Animais
16.
Nature ; 386(6621): 167-70, 1997 Mar 13.
Artigo em Inglês | MEDLINE | ID: mdl-9062187

RESUMO

To look at or reach for what we see, spatial information from the visual system must be transformed into a motor plan. The posterior parietal cortex (PPC) is well placed to perform this function, because it lies between visual areas, which encode spatial information, and motor cortical areas. The PPC contains several subdivisions, which are generally conceived as high-order sensory areas. Neurons in area 7a and the lateral intraparietal area fire before and during visually guided saccades. Other neurons in areas 7a and 5 are active before and during visually guided arm movements. These areas are also active during memory tasks in which the animal remembers the location of a target for hundreds of milliseconds before making an eye or arm movement. Such activity could reflect either visual attention or the intention to make movements. This question is difficult to resolve, because even if the animal maintains fixation while directing attention to a peripheral location, the observed neuronal activity could reflect movements that are planned but not executed. To address this, we recorded from the PPC while monkeys planned either reaches or saccades to a single remembered location. We now report that, for most neurons, activity before the movement depended on the type of movement being planned. We conclude that PPC contains signals related to what the animal intends to do.


Assuntos
Motivação , Atividade Motora/fisiologia , Lobo Parietal/fisiologia , Animais , Braço/fisiologia , Atenção/fisiologia , Sinais (Psicologia) , Macaca , Neurônios Motores/fisiologia , Vias Neurais , Neurônios/fisiologia , Movimentos Sacádicos/fisiologia
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