NMO-DBr: the Brazilian Neuromyelitis Optica Database System.

OBJECTIVE: To present the Brazilian Neuromyelitis Optica Database System (NMO-DBr), a database system which collects, stores, retrieves, and analyzes information from patients with NMO and NMO-related disorders. METHOD: NMO-DBr uses Flux, a LIMS (Laboratory Information Management Systems) for data management. We used information from medical records of patients with NMO spectrum disorders, and NMO variants, the latter defined by the presence of neurological symptoms associated with typical lesions on brain magnetic resonance imaging (MRI) or aquaporin-4 antibody seropositivity. RESULTS: NMO-DBr contains data related to patient's identification, symptoms, associated conditions, index events, recurrences, family history, visual and spinal cord evaluation, disability, cerebrospinal fluid and blood tests, MRI, optic coherence tomography, diagnosis and treatment. It guarantees confidentiality, performs cross-checking and statistical analysis. CONCLUSION: NMO-DBr is a tool which guides professionals to take the history, record and analyze information making medical practice more consistent and improving research in the area.

NMO-DBr: the Brazilian Neuromyelitis Optica Database System / NMO-DBr: o banco de dados brasileiro em neuromielite óptica

OBJECTIVE: To present the Brazilian Neuromyelitis Optica Database System (NMO-DBr), a database system which collects, stores, retrieves, and analyzes information from patients with NMO and NMO-related disorders. METHOD: NMO-DBr uses Flux, a LIMS (Laboratory Information Management Systems) for data management. We used information from medical records of patients with NMO spectrum disorders, and NMO variants, the latter defined by the presence of neurological symptoms associated with typical lesions on brain magnetic resonance imaging (MRI) or aquaporin-4 antibody seropositivity. RESULTS: NMO-DBr contains data related to patient's identification, symptoms, associated conditions, index events, recurrences, family history, visual and spinal cord evaluation, disability, cerebrospinal fluid and blood tests, MRI, optic coherence tomography, diagnosis and treatment. It guarantees confidentiality, performs cross-checking and statistical analysis. CONCLUSION: NMO-DBr is a tool which guides professionals to take the history, record and analyze information making medical practice more consistent and improving research in the area.

OBJETIVO: Apresentar o Brazilian Neuromyelitis Optica Database System (NMO-DBr), um sistema de banco de dados que coleta, arquiva, recupera e analisa informações de pacientes com neuromielite óptica (NMO) e doenças relacionadas. MÉTODO: NMO-DBr usa o sistema Flux, um LIMS (Laboratory Information Management Systems) para gerenciamento de informações. As informações foram colhidas dos prontuários de pacientes com espectro de NMO e variantes de NMO, estas últimas definidas por quadro neurológico associado a lesões encefálicas típicas à imagem pela ressonância magnética (IRM) ou à soropositividade do anticorpo anti-aquaporina-4. RESULTADOS: NMO-DBr contém dados relativos a identificação, sintomas, condições associadas, eventos índices, recorrências, história familiar, avaliação visual e da medula, incapacidade, exames do líquor e de sangue, IRM, tomografia de coerência óptica (OCT), diagnóstico e tratamento. O sistema assegura confidencialidade, cruza dados e faz análises estatísticas. CONCLUSÃO: NMO-DBr é uma ferramenta que possibilita a prática médica mais consistente e promove a pesquisa na área.

PRODIS: a proteomics data management system with support to experiment tracking.

BACKGROUND: A research area that has greatly benefited from the development of new and improved analysis technologies is Proteomics and large amounts of data have been generated by proteomic analysis as a consequence. Previously, the storage, management and analysis of these data have been done manually. This is, however, incompatible with the volume of data generated by modern proteomic analysis. Several attempts have been made to automate the tasks of data analysis and management. In this work we propose PRODIS (Proteomics Database Integrated System), a system for proteomic experimental data management. The proposed system enables an efficient management of the proteomic experimentation workflow, simplifies controlling experiments and associated data and establishes links between similar experiments through the experiment tracking function. RESULTS: PRODIS is fully web based which simplifies data upload and gives the system the flexibility necessary for use in complex projects. Data from Liquid Chromatography, 2D-PAGE and Mass Spectrometry experiments can be stored in the system. Moreover, it is simple to use, researchers can insert experimental data directly as experiments are performed, without the need to configure the system or change their experiment routine. PRODIS has a number of important features, including a password protected system in which each screen for data upload and retrieval is validated; users have different levels of clearance, which allow the execution of tasks according to the user clearance level. The system allows the upload, parsing of files, storage and display of experiment results and images in the main formats used in proteomics laboratories: for chromatographies the chromatograms and lists of peaks resulting from separation are stored; For 2D-PAGE images of gels and the files resulting from the analysis are stored, containing information on positions of spots as well as its values of intensity, volume, etc; For Mass Spectrometry, PRODIS presents a function for completion of the mapping plate that allows the user to correlate the positions in plates to the samples separated by 2D-PAGE. Furthermore PRODIS allows the tracking of experiments from the first stage until the final step of identification, enabling an efficient management of the complete experimental process. CONCLUSIONS: The construction of data management systems for Proteomics data importing and storing is a relevant subject. PRODIS is a system complementary to other proteomics tools that combines a powerful storage engine (the relational database) and a friendly access interface, aiming to assist Proteomics research directly at data handling and storage.

Trabalho e saúde dos professores de educação física nas escolas municipais do Rio de Janeiro / Labor health of teachers of Physical Education in municipal schools in Rio de Janeiro

Esta dissertação buscou fazer uma reflexão acerca dos principais motivosque geraram um quadro de desânimo, desgaste físico e outros problemas desaúde encontrados de uma forma em geral nos professores da rede Municipal do Rio de Janeiro, em especial os docentes de Educação Física. A partir dos referenciais teóricos e metodológicos do campo da medicinado trabalho e saúde do trabalhador, pretende-se analisar saúde e qualidadede vida aliadas à atividade do docente de Educação Física, em seu cotidiano de convivência e trabalho. A nossa pesquisa buscou compreendera qualidade de vida no ambiente de trabalho e suas ações possíveis sobre asaúde do docente de Educação Física. Para tal deu-se um destaque ao localde trabalho desse profissional, ou seja, a escola, pois acreditamos ser umponto vital que precisa ser analisado. A saúde do trabalhador nos levou aocampo das pesquisas em saúde, entendidas como um caminho para secompreender as relações não apenas técnicas, mas também sociais juntoaos professores da rede municipal do Rio de Janeiro. O trabalho de campose deu no próprio espaço de atuação desse profissional – a escola. Atravésde observações participativas e entrevistas semi-estruturadas pode-seperceber como ocorrem às práticas do docente de Educação Física, suainteração social, as atividades realizadas, bem como sua rotina laboral. O estudo visou identificar as relações das atividades do trabalho como a saúdedesse profissional para mostrar que, a partir de um processo de conhecimento e condições de trabalho é possível uma mudança que permita que o ambiente de trabalho se torne menos prejudicial à saúde do professor de Educação Física.

The following essay sought to make a reflection about the main reasons which caused a condition of discouragement, as well as physical exhaustion and other health problems mostly found in teachers from the school chains of the Municipality in Rio de Janeiro –specially Physical Education teachers. Based on both methodological and theoretical background in the field of work medicine in addition to workers' health, health and quality of life (the latter linked to the activities of Physical Education teachers regardingtheir personal and professional everyday life. Our research aimed to comprehend the quality of life when it comes to the work environment and its possible effects on the health of the Physical Education teacher. Therefore emphasis has been given to thisprofessional's workplace, i.e. the school -for we believe it to be a crucial point to be analysed. The worker's health led us to the field of researches concerning health, seen as a way to grasp the relationships -not only technical but also social in relation to teachers from the Municipality of Rio de Janeiro. The work was conducted at the professional's workplace: the school. Through participating observations as well as semi-structured interviews, we could see how the practices of the Physical Education teacher areconducted, his/her social interaction, activities performed besides his/ her working routine. This study tried to identify the relationships between the working activities and this professional's health to show that, from an understanding process and workingconditions, it's possible make a change which allows the work environment to become less harmful to the health of the Physical Education teacher.