[The value of parameters of iron metabolism in the differential diagnosis of anemias]. / Die Wertigkeit von Parametern des Eisenstoffwechsels in der Differentialdiagnose von Anämien.

As a result of investigations into the diagnostic validity of selected haematologic-morphological and clinical-chemical test factors of iron metabolism in the diagnosis of hypochromic anaemia, the examined test faktora are differently evaluated as individual parameters and in their combination. 1. Haematocrit (PCV) is equal to the determination of haemoglobin concentration as a search parameter. 2. The number of reticulocytes, copper and zinc as well as caeruloplasmin have a separating effect as individual parameters on the examined classes of iron deficiency and tumour and infect anaemia. 3. Iron has no value as a individual parameter. It is only in combination with TEBK and the haematologic test factors that is has a diagnostic value. 4. In contrast, ferritin as an individual parameter is of primary importance and should be used extensively in the laboratory diagnosis of hypochromic anaemia. 5. TEBK and transferrin may be supposed to be equal in their diagnostic value. 6. When used in combination, haemoglobin, MCV, TEBK, Transferrin, and ferritin have effective separating function. They permit hypochromic anaemia to be widely assigned to one or another kind of the examined classes.

[Optimizing the diagnosis of anemia]. / Optimierung der Diagnostik von Anämien.

The specific value of the erythrocyte parameters MCH and MCV for the differential-diagnostic arrangement of anaemias to the use of the haematological automations of analysis PHA 1/2 is represented. A prerequisite is the precise determination of haemoglobin concentration and erythrocyte number. MCHC has no sufficient discriminatory capacity.

[The ultrastructure of megathrombocytes in May-Hegglin's anomaly]. / Zur Ultrastruktur der Megathrombozyten bei der May-Hegglinschen Anomalie.

A clinical and extensive electron microscopic study was made of the circulating granulocytes and thrombocytes from three female patients of a family with May-Hegglin anomaly. There have been observed inclusion bodies (Döhle-bodies) in a high proportion of polymorphonuclear leukocytes as well as a thrombocytopenia and giant platelets (so-called megathrombocytes). Other family members did not show hematologic abnormalities. The investigated giant platelets show ultrastructurally a different electron density of the alpha-granules, however, these structures present no typical formation of "bull's eye granules" which has been observed in other cases of May-Hegglin anomaly. Peripheral or central situated net-like structures of the endoplasmic reticulum have been found frequently. There were seen no microtubuli whereas glycogen particles were scattered within the peripheral cytoplasm.