RESUMO
Basaloid follicular hamartoma (BFH) is a rare follicular hamartoma of benign nature, which should be part of the differential diagnoses of basal cell carcinoma. Familial multiple BFH (FMBFH) is a hereditary subtype which typically presents early in life with multiple small, skin-colored papules primarily on the central face. Although these lesions are usually asymptomatic, they can be cosmetically disfiguring. Treatment options include surgery, cryotherapy, CO2 laser and imiquimod; no standard of care has been determined. We present a case of FMBFH presenting in adulthood, which was treated with CO2 laser with satisfactory results.
Assuntos
Dermatoses Faciais/patologia , Hamartoma/patologia , Adulto , Feminino , HumanosRESUMO
Gout is a multisystem disease that may present in different ways. We report an elderly man who presented with a large ulcer of the left leg with hard yellow projections evolving for one year. Analytical study revealed a normal uric acid level, but histopathology showed a focal basophilic acellular material compatible with a gouty tophus. This tophus represents the cardinal feature of advanced gout and may present several challenges to wound care professionals. In fact, the ulcer in our patient persisted after one-year follow-up. Our aim is to alert clinicians about a rare cutaneous presentation of gout that may be increasingly diagnosed.
Assuntos
Gota/patologia , Úlcera da Perna/patologia , Idoso de 80 Anos ou mais , Gota/complicações , Humanos , Úlcera da Perna/etiologia , Masculino , Obesidade/complicações , Ácido Úrico/sangueAssuntos
Antialérgicos/uso terapêutico , Fatores de Troca do Nucleotídeo Guanina/genética , Imunoglobulina E/metabolismo , Síndrome de Job/tratamento farmacológico , Mutação/genética , Omalizumab/uso terapêutico , Fator de Transcrição STAT3/genética , Adulto , Eczema , Eosinofilia , Humanos , Imunoglobulina E/imunologia , Síndrome de Job/genética , MasculinoRESUMO
No disponible
Assuntos
Humanos , Masculino , Adulto , Hipersensibilidade Imediata/tratamento farmacológico , Antialérgicos/uso terapêutico , Omalizumab/uso terapêutico , Resultado do Tratamento , SeguimentosRESUMO
No disponible
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Hiperceratose Epidermolítica/patologia , Histiocitoma Fibroso Benigno/patologia , Neoplasias Cutâneas/patologia , Fibroma/patologia , Diagnóstico Diferencial , Angiofibroma/patologia , Neoplasias Cutâneas/diagnóstico , Nariz/patologiaRESUMO
No disponible
Assuntos
Humanos , Masculino , Adulto , Síndrome de Birt-Hogg-Dubé/genética , Folículo Piloso/patologia , Mutação/genética , BiópsiaRESUMO
No disponible
Assuntos
Humanos , Feminino , Adulto , Alopecia/etiologia , Embolização Terapêutica/efeitos adversos , Aneurisma Intracraniano/terapia , Aneurisma Roto/terapia , Alopecia/patologiaRESUMO
Porokeratosis is a group of hereditary or acquired diseases with abnormal epidermal keratinization. A 71-year-old man was admitted to the Surgery Department after an attack of acute pancreatitis complicated with pancreatic necrosis, which required surgical resection. Three weeks after the admission, the patient was observed by our Dermatology department with sudden onset of a generalized eruption of asymptomatic flat papules with a hyperkeratotic rim, sparing the face, palms, soles, and mucous membranes. A skin biopsy was performed at the border of a leg lesion, which disclosed the presence of cornoid lamella, confirming the clinical diagnosis of disseminated superficial porokeratosis (DSP). The skin eruption spontaneously subsided about one month after pancreatic resection. The late onset of DSP in our patient may represent a type of immunosuppression-induced porokeratosis. Possibly, the pathologic clone of keratinocytes for porokeratosis was present, but remained latent until there was a decrease in the immunological status. It is possible that this relative and transient state of immunosuppression was the result of the concurrent necrotizing pancreatitis. This case represents an unusually good outcome of DSP. To the authors best knowledge, this is the first case of DSP related to severe acute pancreatitis.
Assuntos
Pancreatectomia , Pancreatite/cirurgia , Poroceratose/etiologia , Poroceratose/patologia , Complicações Pós-Operatórias/patologia , Doença Aguda , Idoso , Humanos , Masculino , Necrose , Pâncreas/patologia , Pancreatite/patologia , Poroceratose/fisiopatologia , Complicações Pós-Operatórias/fisiopatologia , Remissão EspontâneaAssuntos
Folículo Piloso/patologia , Doenças da Unha/etiologia , Doenças da Unha/patologia , Transtornos da Pigmentação/etiologia , Transtornos da Pigmentação/patologia , Adulto , Biópsia , Folículo Piloso/metabolismo , Humanos , Queratina-19/metabolismo , Lasers de Gás , Terapia com Luz de Baixa Intensidade , Doenças da Unha/radioterapia , Unhas/patologia , Transtornos da Pigmentação/radioterapiaRESUMO
Rowell syndrome is a rare distinctive entity first described in 1963 by Rowell and coworkers. It consists in erythema multiforme-like lesions associated with lupus erythematosus. Zeitouni et al. recently redefined the major and minor diagnostic criteria. Major criteria are lupus erythematosus, erythema multiforme-like lesions and speckled pattern of antinuclear antibody. Minor criteria are chilblains, positive anti-La (SS-B) or anti-Ro (SS-A) antibody and reactive rheumatoid factor. We report a case of a 63-year-old woman, with no previous history of lupus erythematosus, who developed erythema multiforme-like lesions and laboratory findings consistent with Rowell syndrome.
