RESUMO
Keloid is an aberrant scarring process of the skin, characterized by excessive extracellular matrix synthesis and deposition. The pathogenesis of this prevalent cutaneous disorder is not fully understood; however, a persistent inflammatory process is observed. To obtain more insight into this process, we analyzed lesional, perilesional and healthy tissue using multi-antigen-analysis (MAA) in conjunction with a data mining approach. Here, we demonstrate that monocyte-derived inflammatory dendritic cells (CD1a+, CD11c+, CD14+) and activated CD4+ T lymphocytes (CD45 RO+) dominated the immune infiltration in keloids while associating with fibroblasts. In perilesional tissue, precursor immune cells were dominant in the perivascular area, suggesting that they were attracted by an immune process, potentially in the lesional area. Supporting this hypothesis, only in keloid lesions, high levels of ADAM10/17 and Neprilysin (CD10) were observed in both fibroblasts and leukocytes. The spatial proximity of these two cell types, which could be confirmed by image analysis only in lesional tissue, could be a potential factor leading to the activation of fibroblasts. Our findings provide new insight into the pathogenesis of keloid formation and reveal metalloproteinases as a target for therapeutical intervention.
Assuntos
Proteína ADAM17/metabolismo , Células Dendríticas/imunologia , Fibroblastos/patologia , Inflamação/patologia , Queloide/patologia , Neprilisina/metabolismo , Adolescente , Adulto , Estudos de Casos e Controles , Células Cultivadas , Fibroblastos/imunologia , Fibroblastos/metabolismo , Humanos , Inflamação/imunologia , Inflamação/metabolismo , Queloide/imunologia , Queloide/metabolismo , Pessoa de Meia-Idade , Adulto JovemAssuntos
Carcinoma de Células Escamosas/diagnóstico , Neoplasias Induzidas por Radiação/diagnóstico , Radioisótopos/efeitos adversos , Neoplasias Cutâneas/diagnóstico , Tantálio/efeitos adversos , Adulto , Feminino , Hemangioma/radioterapia , Humanos , Neoplasias Cutâneas/radioterapia , Coxa da PernaRESUMO
We report a case of severe "bodybuilding acne" in a 22-year-old patient. Treatment with isotretinoin paradoxically led to exaceibation and occurrence of pyogenic granuloma-like lesions.
Assuntos
Acne Vulgar , Anabolizantes/efeitos adversos , Androgênios/efeitos adversos , Fármacos Dermatológicos/efeitos adversos , Granuloma Piogênico/induzido quimicamente , Isotretinoína/efeitos adversos , Testosterona/efeitos adversos , Acne Vulgar/induzido quimicamente , Acne Vulgar/tratamento farmacológico , Acne Vulgar/patologia , Adulto , Antibacterianos/uso terapêutico , Causalidade , Cefotiam/uso terapêutico , Tecido de Granulação/efeitos dos fármacos , Humanos , Inflamação , Masculino , Necrose , Supuração , Levantamento de PesoRESUMO
Multifocal disseminated lesions of circumscribed lipoatrophy have not been described as an adverse reaction of intravenously applied drugs. A unique patient with adrenal insufficiency is reported who received corticosteroids intravenously and then had multiple lesions develop that were similar to focal lipoatrophy as known to occur secondary to faulty intradermal injections of corticosteroids.