1.
Res Commun Chem Pathol Pharmacol
; 10(2): 227-38, 1975 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-808840
RESUMO
The metabolic disposition.of zolazepam, a pyrazolodiazepinone, was studied in male and female Spartan rats, Beagle dogs and Rhesus monkeys. Six principal urinary metabolites were characterized by gas chromatography and combined gas chromatography-mass spectrometry. The major metabolite in male and female rats was produced by N-demethylation and hydroxylation. In addition, female rats, but not the male demethylated zolazepam at the 1-position. Male and female dogs also demethylated zolazepam in the 1-position and hydroxylated in a position other than C-6, producing a metabolite peculiar to the dog. In marked contrast, the major metabolite in the monkey involved demethylation without subsequent hydroxylation.
Assuntos
Azepinas/metabolismo , Tranquilizantes/metabolismo , Animais , Azepinas/urina , Cromatografia Gasosa , Cães , Feminino , Fluorbenzenos/metabolismo , Fluorbenzenos/urina , Haplorrinos , Macaca mulatta , Masculino , Espectrometria de Massas , Pirazóis/metabolismo , Pirazóis/urina , Ratos , Fatores Sexuais , Especificidade da Espécie , Tranquilizantes/urina
2.
Int J Appl Radiat Isot
; 20(10): 703-9, 1969 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-5347663
3.
Clin Pharmacol Ther
; 10(4): 498-504, 1969.
Artigo
em Inglês
| MEDLINE
| ID: mdl-5793754
4.
In. Annual Leprosy Research Conference, 4. Annual Leprosy Research Conference, 4/Abstracts of papers. San Francisco, U.S. Public Health Service Hospital, 1969. p.462-3.
Não convencional
em Inglês
| Sec. Est. Saúde SP, HANSEN, Hanseníase, SESSP-ILSLACERVO, Sec. Est. Saúde SP
| ID: biblio-1243394