Assuntos
Endotélio Corneano/citologia , Matriz Extracelular/metabolismo , Fibroblastos/citologia , Animais , Polaridade Celular , Forma Celular , Células Cultivadas , Embrião de Galinha , Substância Própria/embriologia , Endotélio Corneano/metabolismo , Fibroblastos/metabolismo , Fibronectinas/metabolismo , Humanos , CoelhosAssuntos
Corantes , Córnea/citologia , Melanócitos/citologia , Neurônios/citologia , Animais , Cobaias , CoelhosRESUMO
PURPOSE: To review the uses and previously proposed mechanisms of action of amniotic membrane transplantation (AMT) and to suggest a new mechanism of action for the effectiveness of AMT in resolving a persistent epithelial defect (PED). METHODS: Significant clinical and experimental publications are reviewed. RESULTS: Evidence from the scientific literature suggests a new hypothesis for the effectiveness of AMT in the reepithelialization of a PED and the reduction of corneal stromal inflammation and continued fibrosis. CONCLUSION: It is suggested that reepithelialization of a PED, and hence the reduction of stromal inflammation and continued fibrosis following reepithelialization, is aided by the combination of oxygenation, moisture and protection of the fragile epithelium by the amniotic membrane.
