RESUMO
Guanfacine (trade name Estulic Sandoz), has turned out to be a very effective antihypertensive drug. During follow-up of 20 men with a hypertensive response to exercise, and with blood pressure values reaching or exceeding 230/120 mmHg, administration of 1-2 mg of the drug daily led to a decrease in heart rate and blood pressure. At the same time, patients' performance during exercise increased considerably, from 705 W prior to guanfacine administration, to 1.128 W after three-week therapy. Of the biochemical parameters monitored, a statistically significant decrease was observed in the levels of cholesterol, triglycerides and non-esterified fatty acids. There was an insignificant decrease in glycaemia.
Assuntos
Anti-Hipertensivos/uso terapêutico , Teste de Esforço , Guanidinas/uso terapêutico , Hipertensão/tratamento farmacológico , Fenilacetatos/uso terapêutico , Pressão Sanguínea/efeitos dos fármacos , Guanfacina , Frequência Cardíaca/efeitos dos fármacos , Humanos , Fatores de RiscoAssuntos
Anti-Hipertensivos/uso terapêutico , Guanidinas/uso terapêutico , Hipertensão/fisiopatologia , Fenilacetatos/uso terapêutico , Adulto , Pressão Sanguínea/efeitos dos fármacos , Doença das Coronárias/diagnóstico , Seguimentos , Guanfacina , Humanos , Hipertensão/tratamento farmacológico , Masculino , Pessoa de Meia-IdadeAssuntos
Flebite/epidemiologia , Varizes/epidemiologia , Adulto , Tchecoslováquia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome , Úlcera Varicosa/epidemiologiaRESUMO
Following on the epidemiological study of cardiovascular diseases carried out in the rural population of Northern Bohemia in 1970 a long-term ischaemic heart disease prevention programme was launched in a group of 2582 men aged between 30-59 years, worked of two automobile plants in the district of Mladá Boleslav. Under der programme "Protected Your Heart", sponsored by the Automobile Works National Enterprise (AZNP), workers were urged to adjust their food intake in keeping with the principles of rational nutrition, to stop smoking and to take regular after-work cross-country 4 km/1 hr walks. No such programme was carried out at the automobile plant LIAZ serving as control.
Assuntos
Doença das Coronárias/prevenção & controle , Serviços de Saúde do Trabalhador , Adulto , Doença das Coronárias/epidemiologia , Tchecoslováquia , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Doença das Coronárias/prevenção & controle , Isquemia/prevenção & controle , Perna (Membro)/irrigação sanguínea , Doenças Profissionais/prevenção & controle , Adulto , Doença das Coronárias/epidemiologia , Tchecoslováquia , Humanos , Indústrias , Isquemia/epidemiologia , Masculino , Pessoa de Meia-IdadeAssuntos
Doença das Coronárias/diagnóstico , Teste de Esforço , Adulto , Eletrocardiografia , Humanos , Masculino , Pessoa de Meia-Idade , RiscoRESUMO
A longitudinal epidemiological study of ischaemic heart disease (IHD) in men aged 40-59 years showed that the five-year incidence of the manifest form was 7.8% in agricultural workers and 9.7% in industrial employees. The corresponding incidence of the latent form was 9.0% and 12.2%, respectively. The differences in the incidence of both forms between the population samples studied was at the border of statistical significance. The importance of risk factors was evaluated on the basis of the score represented by the difference between the respective five-year incidence of IHD in subjects with and without the risk factors concerned. The highest relative scores were found with systolic and diastolic hypertension, positive family history and obesity. For prognostic purposes, the total relative risk, represented by the sum of the scores of the risk factors proved to be useful. Autopsies confirmed that a total relative risk exceeding 40% was a sensitive indicator of morphological substrate of coronary heart disease.
