Assuntos
Isoantígenos/administração & dosagem , Linfoma/prevenção & controle , Animais , Reações Cruzadas , Antígenos H-2 , Imunização , Rim/imunologia , Leucemia L1210/prevenção & controle , Leucemia L5178/prevenção & controle , Fígado/imunologia , Linfoma/mortalidade , Camundongos , Camundongos Endogâmicos DBARESUMO
Immunization with normal allogeneic kidney and liver tissues extends survival of DBA/2Cr mice challenged with a lethal dose of syngeneic L517BY lymphoma cells. Immunization with a combination of tissues from five strains provides far more protection than immunization with tissue from any single strain. It is suggested that the basis of this protective effect is a cross-reactivity or identity between tumor-associated transplantation antigens (TATA) on the L5178Y tumor and non-H-2 alloantigens normally expressed by some allogeneic tissues.
Assuntos
Imunização , Linfoma/imunologia , Animais , Feminino , Rim/imunologia , Fígado/imunologia , Linfoma/mortalidade , Camundongos , Camundongos Endogâmicos A , Camundongos Endogâmicos AKR , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos DBA , Neoplasias Experimentais , Imunologia de TransplantesRESUMO
Subcutaneous injection of normal allogeneic kidney and liver tissues extended survival of DBA/2Cr mice challenged with a lethal dose of syngeneic L5178Y lymphoma cells. Immunization with a combination of tissues from five strains provided far more protection than immunization with tissue from any single strain. It is suggested that the basis of this protective effect is a cross-reactivity or identity between tumor-associated transplantation antigens (TATA) on the L5178Y tumor and non-H-2 alloantigens normally expressed by some allogeneic tissues.
