RESUMO
OBJECTIVE: To report a rare case of endometrial metastasis of cutaneous malignant melanoma, mimicked by histologically xanthomatous lesion. Only about ten other cases of endometrial metastasis of this malignancy have been reported previously. - DESIGN: Case report. - PATIENT: A 60 year old female. - MAIN OUTCOME MEASURE: Fractionated curettage and immunohistologically examination of the tissue. - RESULTS: Due to xanthomatous regressive changes of the metastatic tissue, difficulties in the histological confirmation as a metastasis of an unpigmented malignant melanoma occurred. But immunohistological staining showed positivity for S-100 and MART-1, as did the primary tumour. - CONCLUSIONS: If atypical bleeding in patients with known malignant melanoma of the skin occur endometrial metastasis should be excluded by gynaecologists.
Assuntos
Neoplasias do Endométrio/diagnóstico , Neoplasias do Endométrio/secundário , Endométrio/patologia , Melanoma Amelanótico/diagnóstico , Melanoma Amelanótico/secundário , Neoplasias Cutâneas/patologia , Hemorragia Uterina/etiologia , Antígenos de Neoplasias/análise , Diagnóstico Diferencial , Dilatação e Curetagem , Neoplasias do Endométrio/complicações , Endométrio/química , Evolução Fatal , Feminino , Humanos , Imuno-Histoquímica , Antígeno MART-1 , Melanoma Amelanótico/complicações , Pessoa de Meia-Idade , Proteínas de Neoplasias/análise , Proteínas S100/análiseRESUMO
When given separately, neither butylbiguanide (N1-butylbiguanide-hydrochloride, the active principle of Silubin retard) (75 mg/kg) nor clofibrate (30 mg/kg) decreased the serum triglycerides in normolipaemic rats. In combined administration, however, the two drugs produced a statistically significant average decrease in serum triglycerides by 30%. Simultaneous administration of the two drugs also lowered triglycerides in rats with carbohydrate-induced hypertriglyceridaemia.
