The influence of body mass index and smoking on the age of onset of menopause in women in Bosnia and Herzegovina: a cross-sectional multicentric study.

Introduction: Menopause is the last physiological menstrual period and is a complex process involving the following: endocrine, genitourinary, cardiovascular, and locomotor system, and it leads to vasomotor symptoms and psychological complaints. This study aims to investigate the influence of smoking and body mass index (BMI) as risk factors on the age of onset of menopause in women in Bosnia and Herzegovina. Material and methods: This study included 460 women in natural menopause. The study was conducted in 2 phases: interview and measurement of BMI. Each patient underwent an interview based on the questionnaire, following the verbal consent of the patient, who had previously been explained the nature of the research. Results: The age at which menopause occurs increases with the BMI increase, and it can be described by the regression equation: age = 0.096 × BMI + 45.7, which has statistical significance. The mean age of menopause occurrence in current smokers was lower (47.5 ±0.4 years) than in non-smokers (48.8 ±0.2 years) (p = 0.010). Conclusions: Our study confirmed the statistically significant correlation between smoking, BMI, and age of onset of menopause.

Bone Density and Body Fat Distribution in Postmenopausal Women.

BACKGROUND: In postmenopause there are changes in metabolism of bone tissue and consequent decrease of bone density. With ageing redistribution of fat occurs and an increase in body weight. Because of hormone changes in postmenopause fat is redistributed from gluteofemoral area to the abdominal region. OBJECTIVE: The objective of this study was to examine the relationship between bone density and a body mass index (BMI), and distribution of the fat tissue in women in postmenopause (WHR). METHODS: This research was prospective, and it included total of 83 women, 53 women were in the natural postmenopause and 30 women with the regular menstruation. RESULTS: BMI in women in postmenopause was statistically significantly higher than BMI in women with the regular menstruations (p= 0,005). There was no statistically significant difference between waist hip ratio in women in the postmenopause in relation to the women with the regular menstruations. In women in the postmenopause significant positive correlation between BMI and density of the neck of femur was found (Z and T-score) (p=0,019; p=0,005). There was also significant negative correlation between the WHR and density of the lumbal spine (backbone) in women in the postmenopause (Z-score) (p=0,043). The identical analysis in women with regular menstruations, negative correlation between the density of the lumbal spine was found again (Z-score) and WHR , but the same was highly expressed (p=0,041). The observed correlation between BMI and bone density in this group of women was not statistically significant. CONCLUSION: Based on the presented results we conclude that the higher the BMI (p=0,019; p=0,005) the higher density of the femoral neck postmenopausal women have, and lower bone density of the lumbar spine the higher ratio waist / hip (p = 0.043). In the women with regular menstruation bone density of the lumbar spine is the lower the higher the ratio of waist and hip (p=0,041), while there was no correlation between BMI and bone density in this group of women.

Parity and menarche as risk factors of time of menopause occurrence.

INTRODUCTION: Menopause is the last physiological menstruation and represents a crucial moment in the life of every woman. OBJECTIVE OF THE STUDY: Determine the effect of parity and menarche as risk factors in the time of menopause occurrence. PATIENTS AND METHODS: This study included 460 women in natural menopause. Each patient has undergone an interview based on the questionnaire, following the verbal consent of the patient who was previously explained nature of the research. Statistical analysis of data was carried out by the usual statistical methods of descriptive statistics, using regression models and "hazard ratio" for the period of life compared to the individual parameters. RESULTS: The average age of menopause occurrence in women who gave birth, was somewhat higher (48.6), in comparison to women who did not give birth (47.8), but the difference was not statistically important (t=-1.07, p=0.287). In the study group there was no correlation between the age of menarche occurrence and the age of menopause occurrence. CONCLUSION: There is no correlation between the age of menarche occurrence, parity and age of the menopause.

The association between lipid profile and bone density in postmenopausal women.

AIM: The aim of this research was to examine the correlation between lipid profile and bone density in postmenopausal and premenopausal women. MATERIAL AND METHODS: This research covered 53 subjects who were in postmenopause and 30 subjects who had regular menstruation, older than 45. RESULTS AND DISCUSSION: The postmenopausal subjects have lower bone density of the lumbar spine, if triglyceride levels were higher (p = 0.030) and VLDL is higher (p = 0.032). In subjects with regular menstruation, the density of the neck of the femur was greater if the cholesterol values were higher (p = 0.002) and the density of the lumbar spine was greater where the levels of triglycerides (p = 0.002) and of ApoB (p = 0.026) were higher. In subjects in postmenopause there was a correlation between the density of the lumbar spine (p = 0.04) and the density of the neck of the femur (p = 0.008) with the length of menopause. The effect of lipid profile on bone density differs in women with regular menstruation and in postmenopausal women. The triglyceride levels in postmenopausal women contribute to a reduction in bone density, whilst the effect on bone density in women with regular menstruation is reversed, which indicates that the lipid profile is not an isolated factor affecting bone density, but that other factors, such as oestrogen levels and the length of post-menopause, have a significant effect on bone density.