RESUMO
Patients with psoriasis and chronic hepatitis C virus (HCV) infection are a therapeutic challenge. Systemic psoriasis treatment with methotrexate and acitretin can be hepatotoxic, and interferon (IFN)-alpha for treatment of HCV can worsen psoriasis. Etanercept can be successfully used in patients with psoriasis and HCV. To our knowledge, this is the first case report of etanercept used prophylactically to prevent a psoriatic flare in a patient with HCV treated with IFN-alpha and ribavirin.
Assuntos
Hepatite C Crônica/tratamento farmacológico , Imunoglobulina G/uso terapêutico , Interferon-alfa/efeitos adversos , Psoríase/prevenção & controle , Receptores do Fator de Necrose Tumoral/uso terapêutico , Ribavirina/efeitos adversos , Antivirais/efeitos adversos , Antivirais/uso terapêutico , Toxidermias/etiologia , Toxidermias/prevenção & controle , Quimioterapia Combinada , Etanercepte , Humanos , Interferon-alfa/uso terapêutico , Masculino , Pessoa de Meia-Idade , Psoríase/induzido quimicamente , Ribavirina/uso terapêuticoRESUMO
The stereoselectivities of base-catalyzed enolizations of ketones have been studied by quantum mechanical methods. Transition structures of exo and endo deprotonation of camphor, norcamphor, and dehydronorcamphor have been located with two model bases. Stereoelectronic, torsional, and steric effects on activation energies were assessed. These calculations demonstrate the importance of torsional strain between partial bonds and vicinal bonds on the rates of deprotonation and on related reactions involving the formation of enolates or reactions of enols and enolates.
