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1.
Prog Cardiovasc Dis ; 65: 2-8, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33617896

RESUMO

Peripheral Artery Disease (PAD) is a manifestation of atherosclerosis characterized by diminished perfusion of the limb and a state of dysmetabolism. The asymptomatic PAD phenotype is a relatively recent classification. It is unknown how many people currently live with asymptomatic PAD because there are no universal screening recommendations for patients at risk for PAD. Patients with asymptomatic PAD suffer from a similar risk profile of morbidity and mortality as their counterparts with claudication. Despite this increased risk, there is a dearth of clinical investigations into therapies that specifically benefit the asymptomatic PAD population. At present, current pharmacotherapies that have been studied in PAD patient populations do not stratify by symptom status. We believe that further investigation of the impact of existing therapies in this unique population presents an opportunity to reduce morbidity and mortality due to PAD. This can only be achieved in combination with wide-spread adoption of screening for asymptomatic PAD.


Assuntos
Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Hipolipemiantes/uso terapêutico , Doença Arterial Periférica/terapia , Inibidores da Agregação Plaquetária/uso terapêutico , Comportamento de Redução do Risco , Índice Tornozelo-Braço/economia , Doenças Assintomáticas , Análise Custo-Benefício , Programas de Triagem Diagnóstica/economia , Dieta Saudável , Progressão da Doença , Exercício Físico , Custos de Cuidados de Saúde , Humanos , Doença Arterial Periférica/diagnóstico , Doença Arterial Periférica/economia , Doença Arterial Periférica/mortalidade , Valor Preditivo dos Testes , Abandono do Hábito de Fumar , Resultado do Tratamento
2.
Infect Control Hosp Epidemiol ; 34(9): 961-966, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23917911

RESUMO

OBJECTIVE: To investigate the simultaneous occurrence of more than 1 Clostridium difficile ribotype in patients' stool samples at the time of diagnostic testing. METHODS: Stool samples submitted for diagnostic testing for the presence of toxigenic C. difficile were obtained for 102 unique patients. A total of 95 single colonies of C. difficile per stool sample were isolated on selective media, subcultured alongside negative (uninoculated) controls, and polymerase chain reaction (PCR) ribotyped using capillary gel electrophoresis. RESULTS: Capillary-based PCR ribotyping was successful for 9,335 C. difficile isolates, yielding a median of 93 characterized isolates per stool sample (range, 69-95). More than 1 C. difficile ribotype was present in 16 of 102 (16%) C. difficile infection (CDI) cases; 2 of the 16 mixtures were composed of at least 3 ribotypes, while the remaining 14 were composed of at least 2. CONCLUSIONS: Deep sampling of patient stool samples coupled with capillary-based PCR ribotyping identified a high rate of mixed CDI cases compared with previous estimates. Studies seeking to quantify the clinical significance of particular C. difficile ribotypes should account for mixed cases of disease.


Assuntos
Clostridioides difficile/genética , Enterocolite Pseudomembranosa/microbiologia , Ribotipagem , Eletroforese Capilar/métodos , Fezes/microbiologia , Feminino , Humanos , Masculino , Reação em Cadeia da Polimerase/métodos , Ribotipagem/métodos
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