1.
J Med Chem
; 35(23): 4259-63, 1992 Nov 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1447730
RESUMO
A novel series of diaminoanthraquinones was discovered initially as protein kinase C inhibitors with IC50s in the 50-100 microM range. They exhibited potent tumor cell growth inhibitory activity in vitro without cross resistance to adriamycin. Further evaluation of two of the most active compounds NSC 639365 (3) and NSC 639366 (4) in human tumor cloning assay showed potent cytocidal activity. The results suggest therapeutical potentials against human tumors.