Exercise during early, but not late abstinence, attenuates subsequent relapse vulnerability in a rat model.

Exercise has shown promise as a nonpharmacological intervention for addiction, with evidence suggesting a potential utility for relapse prevention. In humans, exercise as an intervention is typically introduced well after the initiation of abstinence, yet neurobiological data from preclinical studies suggest that it may be more effective if initiated during early abstinence. Here, using rat models, we determined whether the beneficial effects of exercise on relapse vulnerability depends on when exercise is first initiated, during early versus late abstinence. Once rats (n=47) acquired cocaine self-administration, they were given 24-h access to cocaine (1.5 mg/kg per infusion) under a discrete trial procedure (four infusions per hour) for 10 days. The rats then began a 14-day abstinence period in which they had access (2 h per day) to a locked wheel throughout abstinence (sedentary) or an unlocked wheel during early (days 1-7), late (days 8-14) or throughout (days 1-14) abstinence (n=10-14 per group). Cocaine seeking, as assessed under an extinction/cued-induced reinstatement procedure, was examined on day 15 of abstinence. Exercise beginning during early abstinence robustly attenuated subsequent cocaine seeking, and this effect persisted even when exercise ended on the seventh day of abstinence. In contrast, exercise during late abstinence was not effective and these animals displayed high levels of cocaine seeking similar to those observed in sedentary animals. These results indicate that the timing of exercise availability differentially impacts cocaine seeking with results suggesting that exercise during early, but not late, abstinence may provide long-term protection against cocaine relapse.

The prevalence and correlates of depression, anxiety, and stress in a sample of college students.

BACKGROUND: Over the past four years, the Franciscan University Counseling Center has reported a 231% increase in yearly visits, as well as a 173% increase in total yearly clients. This trend has been observed at many universities as mental health issues pose significant problems for many college students. The objective of this study was to investigate potential correlates of depression, anxiety, and stress in a sample of college students. METHODS: The final analyzed sample consisted of 374 undergraduate students between the ages of 18 and 24 attending Franciscan University, Steubenville, Ohio. Subjects completed a survey consisting of demographic questions, a section instructing participants to rate the level of concern associated with challenges pertinent to daily life (e.g. academics, family, sleep), and the 21 question version of the Depression Anxiety Stress Scale (DASS21). RESULTS: The results indicated that the top three concerns were academic performance, pressure to succeed, and post-graduation plans. Demographically, the most stressed, anxious, and depressed students were transfers, upperclassmen, and those living off-campus. CONCLUSIONS: With the propensity for mental health issues to hinder the success of college students, it is vital that colleges continually evaluate the mental health of their students and tailor treatment programs to specifically target their needs.

High-frequency audiometry above 8,000 Hz.

Human auditory sensitivity for the frequencies 8, 10, 12, 16, 18, and 20 kHz was examined in a group of 41 female university students ranging in age from 19 to 22 years. The purpose of this study was twofold: to determine the feasibility of high-frequency testing using procedures routinely employed in clinical audiometry and to collect normative data using this procedure on a young adult population. A modified Hughson Westlake procedure was employed and thresholds were obtained for both ears of each subject. It was noted that for the 20-kHz tone only 52% of the subjects tested were able to respond. Statistical analysis revealed no significant threshold differences between right or left ears for all subjects at any frequency. The approach described in the present study provided reliable thresholds and was found to be clinically feasible. Comparisons were made with similar previous studies and the results of the present study were found to be in general, overall agreement.

Influence of encoding and acoustic similarity on the ear advantage and lag effect in dichotic listening.

Experiments with simultaneous and time lag dichotic listening conditions were used to test two hypotheses concerning the right ear advantage and lag effect in dichotic listening. One hypothesis is based on the similarity of acoustic spectra, and the other is based on a categorization of speech sounds as being either encoded or not encoded. Natural vowels and consonant-vowel syllables were used to obtain seven different types of speech stimuli: stop vowel syllables, fricative vowel syllables, stop burst noise, fricative noise, stop vowel transitions, fricative vowel transitions and steady state vowels. The presentation conditions were monaural, simultaneous dichotic, and dichotic with interaural time delays of 15, 30, 60, and 90 msec. With monaural presentations, all stimuli were identifiable above chance levels. For the simultaneous dichotic condition, significant right ear advantages occurred for stop vowel syllables, fricative vowel syllables, stop burst noise, and steady state vowels. For the time lag conditions, stop vowel syllables, stop bursts, and fricative noise produced consistent lag effects, but steady state vowels produced consistent lead effects. In general, the results gave stronger support to the hypothesis of acoustic similarity than to the encoding hypothesis in that stop burst noise produced both a right ear advantage and a lag effect whereas consonant-vowel transitions produced neither a right ear advantage nor a lag effect.