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1.
J Educ Health Promot ; 12: 264, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37849876

RESUMO

The quality of life (QOL) of patients with multiple sclerosis (MS) is estimated to be poor compared to the general population. Its management is complex thus requiring openness to non-pharmacological approaches such as therapeutic education (TPE). However, there is an abundance of educational programs with several components and varying degrees of effectiveness. This protocol is developed with the objective to determine the impact of TPE programs on the QOL of MS patients. We will undergo research in PubMed, Web of Science, and Scopus to identify all eligible articles published between January 1st, 2007, and February 2022 evaluating the QOL. We will include any quantitative study design: Randomized Controlled Trials (RCTs), non-randomized controlled trials, non-randomized uncontrolled trials, and observational studies. The quality of these studies will be assessed by recommended tools. Two investigators will independently perform the data extractions and any disagreements will be resolved by other reviewers. A narrative synthesis will report results according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist guidelines to draw conclusions based on the totality of the evidence. These results will be summarized by characteristics of studies and programs and by effects on the QOL. This systematic review will provide practice guidance and evidence to effectively target the features and components of TPE programs, to effectively meet the specific needs of MS patients and thereby improve their QOL, and on the other hand to facilitate the appropriation of these programs by clinicians and researchers to optimize the management of MS. Systematic review registration: PROSPERO CRD42022338651.

3.
Neurosciences (Riyadh) ; 15(4): 284-6, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20956930

RESUMO

Hypothyroidism is frequently associated with different neuromuscular disorders. However, myotonia is rarely a revealing feature. We report a case of hypothyroidism secondary to Hashimoto's thyroiditis and myotonia. The patient is a 45-year-old woman who consulted for a progressive myotonia. Blood and thyroid assessments revealed peripheral hypothyroidism with low free thyroxine, high thyroid-stimulating hormone levels and high titers of anti-thyroperoxidase antibodies. Outcome was favorable with thyroid hormone substitution. Hashimoto's thyroiditis is a common cause of hypothyroidism. The frequency of myopathy during hypothyroidism ranges from 30-80%. The main symptoms related are weakness, muscular cramps, and myalgia. Myotonia may reveal hypothyroidism. The pathogenic mechanism of this myotonia is still unknown. Good outcome of hypothyroid manifestations with thyroid hormone substitution requires systematic thyroid hormone screening in patients presenting with neuromuscular manifestations.


Assuntos
Doença de Hashimoto/complicações , Miotonia/etiologia , Eletromiografia/métodos , Feminino , Humanos , Pessoa de Meia-Idade , Miotonia/diagnóstico
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