RESUMO
This study reports on the clinical and histologic features of 2 previously unreported cases of sialadenoma papilliferum. Immunohistochemical analysis of one of the cases demonstrated that the ductal cell component shows both epithelial and myoepithelial differentiation.
Assuntos
Cistadenoma/patologia , Palato/patologia , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares Menores/patologia , Idoso , Antígenos de Neoplasias/análise , Biomarcadores Tumorais/análise , Cistadenoma/química , Cistadenoma/cirurgia , Diagnóstico Diferencial , Células Epiteliais/patologia , Humanos , Masculino , Melanoma/patologia , Pessoa de Meia-Idade , Palato/química , Palato/cirurgia , Ductos Salivares/patologia , Neoplasias das Glândulas Salivares/química , Neoplasias das Glândulas Salivares/cirurgia , Glândulas Salivares Menores/química , Glândulas Salivares Menores/cirurgiaRESUMO
A 52-year-old woman developed recurrent hypercortisolism 3 yr after successful surgical treatment of Cushing's disease. At postmortem, eosinophilic pituitary tissue showing positive ACTH immunohistochemical staining was present in the frontal lobe and cerebellum but there was no tumor in the sella. In the absence of a pituitary tumor, extrasellar ACTH producing tissue could arise from seeding of the cerebrospinal fluid with tumor cells at the time of operation or from an atypical pituitary carcinoma. In this report we review the mechanisms of intracranial dissemination of pituitary tissue and ACTH-secreting pituitary carcinomas, including parasellar invasion, meningeal seeding, and cerebrospinal and hematogenous spread.
Assuntos
Adenoma/metabolismo , Hormônio Adrenocorticotrópico/metabolismo , Neoplasias Hipofisárias/metabolismo , Adenoma/patologia , Adenoma/secundário , Neoplasias Encefálicas/etiologia , Síndrome de Cushing/complicações , Síndrome de Cushing/patologia , Síndrome de Cushing/cirurgia , Dexametasona , Feminino , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Metástase Neoplásica , Neoplasias Hipofisárias/patologia , Neoplasias Hipofisárias/secundárioRESUMO
The authors report a case of complete lymph node infarction in which a specific etiology could not be determined by morphologic or immunophenotypic studies; however, clonal rearrangement of the immunoglobulin gene was demonstrated by Southern blot hybridization of DNA extracted from the necrotic tissue. A subsequent lymph node biopsy later was diagnosed as malignant lymphoma, using morphologic, immunophenotypic and genotypic criteria. Identical clonally rearranged bands were present in DNA from both the infarcted nodal and the subsequent tissue biopsies. In the setting of lymph node necrosis, gene rearrangement studies may provide diagnostic information concerning clonality, even if morphologic and immunophenotypic studies are indeterminate for a lymphoproliferative process.
