RESUMO
This study reports on the clinical and histologic features of 2 previously unreported cases of sialadenoma papilliferum. Immunohistochemical analysis of one of the cases demonstrated that the ductal cell component shows both epithelial and myoepithelial differentiation.
Assuntos
Cistadenoma/patologia , Palato/patologia , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares Menores/patologia , Idoso , Antígenos de Neoplasias/análise , Biomarcadores Tumorais/análise , Cistadenoma/química , Cistadenoma/cirurgia , Diagnóstico Diferencial , Células Epiteliais/patologia , Humanos , Masculino , Melanoma/patologia , Pessoa de Meia-Idade , Palato/química , Palato/cirurgia , Ductos Salivares/patologia , Neoplasias das Glândulas Salivares/química , Neoplasias das Glândulas Salivares/cirurgia , Glândulas Salivares Menores/química , Glândulas Salivares Menores/cirurgiaRESUMO
The authors report a case of complete lymph node infarction in which a specific etiology could not be determined by morphologic or immunophenotypic studies; however, clonal rearrangement of the immunoglobulin gene was demonstrated by Southern blot hybridization of DNA extracted from the necrotic tissue. A subsequent lymph node biopsy later was diagnosed as malignant lymphoma, using morphologic, immunophenotypic and genotypic criteria. Identical clonally rearranged bands were present in DNA from both the infarcted nodal and the subsequent tissue biopsies. In the setting of lymph node necrosis, gene rearrangement studies may provide diagnostic information concerning clonality, even if morphologic and immunophenotypic studies are indeterminate for a lymphoproliferative process.
