Assuntos
Nistatina/uso terapêutico , Psoríase/tratamento farmacológico , Adulto , Idoso , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Heat-killed sonicated suspensions of malassezia ovalis and Staphylococcus epidermidis were applied to the intact volar surface of the forearm of ten patients with psoriasis and ten control subjects. All ten of the patients with psoriasis reacted to M ovalis, and four patients reacted to S epidermidis. Two of the control subjects responded to M ovalis, and none responded to S epidermidis. Lesions that both clinically and histologically were consistent with those of psoriasis developed in the patients with psoriasis.
Assuntos
Malassezia/imunologia , Psoríase/imunologia , Staphylococcus/imunologia , Adulto , Dermatite Seborreica/imunologia , Eritema/imunologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes do Emplastro , Psoríase/patologia , SonicaçãoAssuntos
Endotoxinas/sangue , Psoríase/sangue , Adulto , Idoso , Consumo de Bebidas Alcoólicas , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Activation of C3 and factor B in normal human serum by P. ovale was demonstrated using a standard unidirectional immunoelectrophoresis technique. Activation of complement by the alternative (properdin) pathway is a possible mechanism by which P. ovale may mediate an inflammatory response.
Assuntos
Ativação do Complemento , Via Alternativa do Complemento , Malassezia/imunologia , Complemento C3/metabolismo , Complemento C3b/metabolismo , Fator B do Complemento/metabolismo , Humanos , ImunoeletroforeseRESUMO
The percentage of total T-lymphocytes was measured in 38 patients with histologically diagnosed squamous cell carcinoma of the head and neck. This measure of cellular immunity, which appears to be important in tumor-cell destruction, is demonstrably lowered in advanced stages of this disease. With the use of this test, the effect of a combined chemoimmunotherapeutic regimen consisting of methotrexate sodium, isoniazid, and BCG vaccine was sutdied. In this small series, no decrease of the T-cell count following treatment by methotrexate was demonstrated, except when a high dosage followed by leucovorin calcium was used. The BCG vaccine appeared to enhance T-cell counts, and one patient who was treated with cryosurgery had a dramatic increase in circulating T-lymphocytes. The T-cell test may be of clinical importance in the development of treatment sequences that provide maximum reduction of tumor cell mass while preserving host T cells.