RESUMO
A stable increase in the rate of birth of children with congenital developmental defects in general and, specifically, with cleft lip and palate was observed in Moscow in 1979-1993. Regions of the city with stable high and low annual incidence of birth of children with maxillofacial clefts were distinguished.
Assuntos
Face/anormalidades , Anormalidades Maxilomandibulares/epidemiologia , População Urbana/estatística & dados numéricos , Fenda Labial/epidemiologia , Fissura Palatina/epidemiologia , Feminino , Humanos , Incidência , Recém-Nascido , Masculino , Morbidade/tendências , Moscou/epidemiologia , Distribuição por SexoRESUMO
Review of literature demonstrated that adverse occupational exposures of the parents caused prezygotic and transplacental changes in both parents and their children. Embryotoxic and teratogenic effects in children of workers engaged in some types of production are described. Analysis of the contribution of parental profession to risk of oncologic diseases in children represents a new trend of studies. Hypotheses on teratogenic and carcinogenic mechanisms of the said changes are offered.
Assuntos
Proteção da Criança , Exposição Ambiental , Doenças Genéticas Inatas/genética , Ocupações , Saúde da Mulher , Mulheres Trabalhadoras , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Pessoa de Meia-IdadeRESUMO
Cytogenetic analysis of lymphocytes was performed in 36 preparatory workers engaged into rubber shoes and general mechanical rubber goods production. Preparatory workers and management staff had the same chromosomal aberrations frequency. Although chromosomal aberrations frequency in employees of the enterprise appeared to be twice as much as that for general population, which proves hazardous factors of rubber production to afflict genofond of employees.
Assuntos
Indústria Química , Aberrações Cromossômicas/genética , Linfócitos/citologia , Exposição Ocupacional , Borracha , Fumar/efeitos adversos , Adulto , Feminino , Humanos , Masculino , Metáfase , Pessoa de Meia-Idade , Fatores de TempoRESUMO
The study covered analysis of reproductive function, incidence of chronical diseases and gynecologic malignancies in rubber female workers. Hazardous work conditions of rubber production were reported to afflict reproductive function promoting gynecologic diseases and to change the structure of oncologic morbidity. Female workers exposed to occupational hazards of rubber production show some long-term effects of the exposure such as reliably increased reproductive impairments. Mechanism of such impairments may be connected with endocrine disbalance especially with estrogen deficit. As a result of it the changed ratio breast/uterus and ovary cancers is found among female rubber workers in comparison with the general population.
Assuntos
Indústria Química , Doenças dos Genitais Femininos/induzido quimicamente , Neoplasias dos Genitais Femininos/induzido quimicamente , Doenças Profissionais/induzido quimicamente , Exposição Ocupacional , Reprodução/efeitos dos fármacos , Borracha/efeitos adversos , Adulto , Doença Crônica , Estudos de Coortes , Feminino , Doenças dos Genitais Femininos/epidemiologia , Neoplasias dos Genitais Femininos/epidemiologia , Humanos , Incidência , Morbidade , Doenças Profissionais/epidemiologiaAssuntos
Neoplasias/epidemiologia , Ocupações , Pais , Adolescente , Adulto , Criança , Pré-Escolar , Exposição Ambiental , Métodos Epidemiológicos , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Neoplasias/etiologia , Projetos de Pesquisa , U.R.S.S.RESUMO
The analysis of publications reveals that this professional risk-group of females is marked by an increase of obstetrical pathology, fetal death and inborn malformations. Animal experiments proved teratogenicity, embryotoxicity and mutagenicity of some compounds to which women are exhibited in resin and plastic producing industries. Increased chromosomal abbreviations have been revealed in somatic cells and embryonal tissue fibroblasts. Elaboration of further preventive measures is needed to lower the risk of health affects in female workers and their children.