[Correlation between structure and radioprotective activity (RPA) in thiazole derivatives]. / Vzaimosvaz struktura-radiozashchitnaia aktivnost (RZA) v riadu proizvodnykh tiazola.

The method of potential functions was used to predict adequately the radioprotective efficacy of thiazole derivative series, the geometrical indexes (1n A2 and A6) and anti-ion mass being applied as descriptors for organic and inorganic molecule parts respectively.

[Prediction of the acute toxicity of benzimidazole compounds by the electron structure of their molecules]. / Prognozirovanie ostroi toksichnosti soedinenii riada benzimidazola po élektronnoi strukture ikh molekul.

The relationship between acute toxicity of benzimidazole series compounds and electron structure of molecules was followed by using the method of potential functions, the method of basic components and the CHARM programme. The principal possibility of predicting toxicity of various derivatives of this class by electron structure of their molecules was shown. The fragment method of the assessment of characteristics in the range of CNDO/2 approximation permitting the quality of prognosis of 86-93% is proposed.