The Interplay of Sports and Nutrition in Neurological Health and Recovery.

This comprehensive review explores the dynamic relationship between sports, nutrition, and neurological health. Focusing on recent clinical advancements, it examines how physical activity and dietary practices influence the prevention, treatment, and rehabilitation of various neurological conditions. The review highlights the role of neuroimaging in understanding these interactions, discusses emerging technologies in neurotherapeutic interventions, and evaluates the efficacy of sports and nutritional strategies in enhancing neurological recovery. This synthesis of current knowledge aims to provide a deeper understanding of how lifestyle factors can be integrated into clinical practices to improve neurological outcomes.

Evolutionary Echoes: A Four-Day Fasting and Low-Caloric Intake Study on Autonomic Modulation and Physiological Adaptations in Humans.

This study evaluates the psychophysiological response to a simulated hunter-gatherer endurance task with restricted caloric intake over four days. It assesses changes in body composition, autonomic modulation, and physical and cognitive performance. Participants underwent daily 8 h fasted walks followed by a 150 kcal meal to replicate hunter-gatherer activity and dietary patterns. Measurements of metabolic, respiratory, and subjective well-being, along with heart rate variability (HRV) monitoring, were conducted pre- and post-activity to evaluate the impact of endurance activity under caloric restriction. We found weight loss, decreased body and visceral fat, and reduced skeletal muscle mass and water percentage. High sympathetic activation and stable urinary markers, except for increased proteinuria, indicated stress responses and muscular degradation. Elevated perceived exertion post-exercise with good adaptation to prolonged effort underlines the body's adaptability to ancestral lifestyle conditions, highlighting the connection among endurance, nutrition, and psychophysiological health.

Advances in Understanding the Interplay between Dietary Practices, Body Composition, and Sports Performance in Athletes.

The dietary practices of athletes play a crucial role in shaping their body composition, influencing sports performance, training adaptations, and overall health. However, despite the widely acknowledged significance of dietary intake in athletic success, there exists a gap in our understanding of the intricate relationships between nutrition, body composition, and performance. Furthermore, emerging evidence suggests that many athletes fail to adopt optimal nutritional practices, which can impede their potential achievements. In response, this Special Issue seeks to gather research papers that delve into athletes' dietary practices and their potential impacts on body composition and sports performance. Additionally, studies focusing on interventions aimed at optimizing dietary habits are encouraged. This paper outlines the key aspects and points that will be developed in the ensuing articles of this Special Issue.

Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities.

Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative disorders, stroke, and psychiatric illnesses. This review paper provides a comprehensive overview of the intricate relationship between mitochondria and brain disease, focusing on the underlying pathological mechanisms and exploring potential therapeutic opportunities. The review covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, mitochondrial dynamics, calcium dysregulation, and reactive oxygen species generation in the context of brain disease. Additionally, it discusses emerging strategies targeting mitochondrial dysfunction, including mitochondrial protective agents, metabolic modulators, and gene therapy approaches. By critically analysing the existing literature and recent advancements, this review aims to enhance our understanding of the multifaceted role of mitochondria in brain disease and shed light on novel therapeutic interventions.

Predictors of Athlete's Performance in Ultra-Endurance Mountain Races.

BACKGROUND: In previous studies, ultra-endurance performance has been associated with training and psychological variables. However, performance under extreme conditions is understudied, mainly due to difficulties in making field measures. AIM: The aim of this study was to analyze the role of training, hydration, nutrition, oral health status, and stress-related psychological factors in athletes' performance in ultra-endurance mountain events. METHODS: We analyzed the variables of race time and training, hydration state, nutrition, oral health status, and stress-related psychological factors in 448 ultra-endurance mountain race finishers divided into three groups according to race length (less than 45 km, 45-90 km, and greater than 90 km), using a questionnaire. RESULTS: Higher performance in ultra-endurance mountain races was associated with better oral health status and higher accumulative altitude covered per week as well as higher positive accumulative change of altitude per week during training. In longer distance races, experience, a larger volume of training, and better hydration/nutrition prior to the competition were associated with better performance. CONCLUSIONS: Ultra-endurance mountain athletes competing in longer races (>90 km) have more experience and follow harder training schedules compared with athletes competing in shorter distances. In longer races, a larger fluid intake before the competition was the single best predictor of performance. For races between 45 and 90 km, training intensity and volume were key predictors of performance, and for races below 45 km, oral health status was a key predictor of performance. Psychological factors previously reported as ultra-endurance mountain race performance predictors were inconsistent or failed to predict the performance of athletes in the present research.

Psychophysiological Stress Response of a Paralympic Athlete During an Ultra-Endurance Event. A Case Study.

Psychophysiological response of athletes with spinal cord injurie has not been reported yet in scientific literature. The aim of this study is to examine the psychophysiological stress response of Paralympic athlete during competitive activities. We collected the following psychophysiological measurements: anxiety-trait, anxiety-state, locus of control, perceived psychological stress, stress-copying style, rate of perceived exertion, perceived muscle pain, body temperature, forced vital capacity, blood oxygen saturation, blood glucose and lactate concentrations, isometric hand strength, cortical arousal, heart rate variability, heart rate and velocities of a female Paralympic spinal cord injured athlete in a 11 h and 44 min ultraendurance mountain event. An ultraendurance mountain even produced an increase in the sympathetic autonomous modulation, heart rate, lactate, muscular pain and rated of perceived exertion and a decrease in cortical arousal, hand strength and respiratory muscle in a spinal cord injurie female athlete during. The Paralympic athletes presented a low psychological inflexibility, high life engagement, strong internal locus of control, a low trait and state anxiety and medium perceived psychological stress. These results are consistent with the expected response during a highly stressful situation and consistent with previous findings in athletes without spinal cord injurie.

Multidisciplinary Analysis of Differences Between Finisher and Non-finisher Ultra-Endurance Mountain Athletes.

Ultra-endurance races are one of the most physically and psychologically demanding sports, depending performance on several elements. The aims of the present study were (i) to analyze differences in selected psychophysiological parameters between finisher and non-finisher ultra-endurance mountain athletes, and (ii) to analyze modifications in psychophysiological parameters before and after an ultra-endurance mountain event. Selected psychophysiological variables were assessed in 46 finishers and 24 non-finishers in two over 100 km ultra-endurance races were examined. We found how an ultra-endurance mountain race produced dehydration, a decrease in systolic blood pressure, weight and leg strength muscle values, as well as an increase in heart rate and rate of perceived exertion values. Finishers presented lower systolic blood pressure, weight, body mass index, half marathon time and fluid intake before competition day compared to non-finishers. In addition, body mass index, pre-race hydration, and performance in lower distance races were predictors of performance in these ultra-endurance mountain races.

Nutrition, hydration and ergogenic aids strategies in ultraendurance mountain events.

BACKGROUND: The purpose of the present research was to analyze nutrition, hydration and ergogenic aids strategies in ultraendurance mountain events. METHODS: A total of 386 ultraendurance mountain races finishers were analyzed. They were divided into three groups according to their race distance: G1, distance less than 45 km (N.=250); G2, distances between 45 and 90 km (N.=71); G3, distances longer than 90 km (N.=65). The ergogenic, nutritional and hydration strategies were quantified after each race by a questionnaire. RESULTS: We found a higher ingestion of (0.56±0.95), caffeine (G3 203.8±211.5 mg), water (G3 7.1±3.7 l) and portion of sandwich (nutrition 5.3±7.4) nonsteroidal anti-inflammatory drug (NSAID) in longer distance probes. Higher performance runners in low and medium distances consumed a significantly (P>0.05) lower quantity of gels (higher 0.76±0.98 vs. lower 1.38±1.38), and muesli bar (higher 1.09±1.13 vs. lower 2.04±1.94), and in long distances higher performance consumed more water (M±SD; higher 8.23±3.92 vs. lower 6.12±3.28) than lower performance ones. They also could maintain a higher rated of perceived exertion than lower performance (G3 M±SD; higher 16.7±2.28 vs. lower 18.2±1.71). CONCLUSIONS: Higher distance presented higher nutritional, caffeine and NSAIDs ingestion than lower distances, also, higher performance athletes of higher distance presenter higher water and nutritional ingestion than lower performance ones. In lower distance probes, higher performance athletes presented lower hydration and nutritional ingestion than lower performance athletes.

Psychophysiological, Body Composition, Biomechanical and Autonomic Modulation Analysis Procedures in an Ultraendurance Mountain Race.

The current research aimed to analyze psychophysiological, body composition, biomechanical and autonomic modifications in an ultraendurance mountain race. We analyzed 11 finisher voluntary athletes that participated in a 51.2 km ultraendurance mountain race. We measured before and after the mountain ultraendurance event the following parameters: Rate of perceived exertion, body composition, cortical arousal, blood pressure, body temperature, forced vital capacity, blood oxygen saturation, isometric hand strength and heart rate variability parameters. The results of temperature, rate of perceived exertion, heart rate and the percentage of body water at the end of the race increased significantly. However, the variables of body weight, body fat, muscle, body mass index, abdominal fat, blood oxygen saturation, systolic and diastolic blood pressure, cortical arousal and hands and legs strength significantly decreased after the race. The square root of the average of the sum of the differences squared between normal adjacent R-R intervals, percentage of differences between normal adjacent R-R intervals, high-frequency, sensitivity of the short-term variability, and long-term variability decreased significantly after the race. By contrary low-frequency increased significantly at the end of the race. An ultraendurance mountain event produced a large anticipatory anxiety response, an increase in sympathetic modulation, body fat consumption, percentage of body water, and RPE, not affecting the cortical arousal.