RESUMO
The article presents data of Cancer Registry in Novosibirsk for the period 1988-2012 concerning primary liver cancer. Over the period studied the incidence and mortality have declined significantly (2,5 and 2,1 times, respectively). Both figures fall in line for men and women being generally twice as high in men. The long-term trends of main etiologic risk factor for liver cancer (prevalence of hepatitis viruses B and C in the population) are shown. The issues of screening and prevention are discussed.
Assuntos
Hepacivirus , Vírus da Hepatite B , Hepatite B/epidemiologia , Hepatite C/epidemiologia , Neoplasias Hepáticas , Sistema de Registros , Humanos , Incidência , Neoplasias Hepáticas/epidemiologia , Neoplasias Hepáticas/virologia , Estudos Retrospectivos , Sibéria/epidemiologiaRESUMO
The analysis of noninvasive diagnostics of a phenotype of gastritis among 1050 people aged from 18 till 80 years which consistently addressed to policlinic is presented in the article. The instrument of diagnostics was a <
Assuntos
Anticorpos Antibacterianos/sangue , Gastrinas/sangue , Gastrite , Helicobacter pylori , Imunoglobulina G/sangue , Pepsinogênio A/sangue , Pepsinogênio C/sangue , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Gastrite/sangue , Gastrite/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
This review deals with pepsinogen metabolism, physiological role, and clinical implications. Effects of various factors, e.g H. pylori, on pepsinogen levels are considered. It is concluded that non-invasive screening of gastric precancer conditions provides a cost-effective and efficacious approach to the prevention of this pathology.
Assuntos
Infecções por Helicobacter/diagnóstico , Infecções por Helicobacter/metabolismo , Pepsinogênios , Infecções por Helicobacter/patologia , Helicobacter pylori/patogenicidade , Humanos , Pepsinogênios/química , Pepsinogênios/fisiologia , Neoplasias Gástricas/química , Neoplasias Gástricas/metabolismo , Neoplasias Gástricas/microbiologiaRESUMO
Available experimental and clinical data on the role of the L-carnitine system in the organism of mammals in the state of alcohol intoxication are summarized. Possible mechanisms of the protective action of L-carnitine in cases of alcohol injury are considered.
Assuntos
Alcoolismo/tratamento farmacológico , Carnitina/administração & dosagem , Alcoolismo/metabolismo , Animais , Carnitina/metabolismo , Depressores do Sistema Nervoso Central/administração & dosagem , Depressores do Sistema Nervoso Central/metabolismo , Avaliação Pré-Clínica de Medicamentos , Etanol/administração & dosagem , Etanol/metabolismo , HumanosRESUMO
We have studied the distribution of genotypes of the MTHFR gene among the Siberian female population and compared it with the frequency of this mutation in different populations. The TT genotype and the T allele frequency in 299 women from Novosibirsk (West Siberia) was determined. The presence of the C677T allele was determined by PCR and Hinf I digestion. The homozygous genotype TT was detected in 8.69% of the population sample. The frequency of the C677T mutant allele was found to be 0.290.
