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1.
Acta Diabetol ; 2024 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-38833007

RESUMO

AIMS: To assess the effectiveness of the intermittent-scanned continuous glucose monitoring (isCGM) system in preventing severe hypoglycemic episodes and in improving glucose parameters and quality of life. METHODS: Four hundred T1D individuals were enrolled in a prospective real-word study with an intermittently scanned continuous glucose monitoring device during the 12-months follow-up. The primary endpoint was the incidence of severe hypoglycemic events. RESULTS: 82% of subjects were naïve to the use of the device (group A) and 18% were already wearing the system (group B). The cumulative incidence of severe hypoglycemia (SH) at 12 months was 12.06 per 100 person-year (95% CI: 8.35-16.85) in group A and 10.14 (95% CI: 4.08-20.90) in group B without inter-group differences. In group A there was a significant decrease in SH at 12 months compared to 3 months period (p = 0.005). Time in glucose range significantly increased in both groups accompanied with a significant decrease in glucose variability. HbA1c showed a progressive significant time-dependent decrease in group A. The use of the device significantly improved the perceived quality of life. CONCLUSION: This study confirmed the effectiveness of the isCGM in reducing hypoglycemic risk without glucose deterioration, with potential benefits on adverse outcomes in T1D individuals. TRIAL REGISTRATION: ClinicalTrials.gov registration no. NCT04060732.

2.
Curr Opin Obstet Gynecol ; 26(2): 83-91, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24535321

RESUMO

PURPOSE OF REVIEW: The aim of this article is two-fold: to report the prevalence of herbal products used by pregnant women and to evaluate the evidence of efficacy and safety of the most popular remedies. RECENT FINDINGS: Of the 671 articles identified, 15 randomized controlled trials (RCTs) and 16 non-RCTs were eligible. Ginger was the most investigated remedy and it was consistently reported to ameliorate nausea and vomiting in pregnancy. Although raspberry, blue cohosh, castor oil, and evening primrose oil are believed to facilitate labor in traditional medicine, very few scientific data support such indication. Moreover, they have been associated with severe adverse events. Data on the safety of Hypericum perforatum in pregnancy or lactation are reassuring, whereas efficacy was demonstrated only in nonpregnant individuals. There is still insufficient evidence regarding the efficacy and safety of Echinacea, garlic, and cranberry in pregnancy. SUMMARY: Epidemiological studies reported a wide range of use of herbal remedies in pregnancy. Too few studies have been devoted to the safety and efficacy of singular herbs. With the exception of ginger, there are no consistent data to support the use of any other herbal supplement during pregnancy. Severe adverse events have been reported using blue cohosh and evening primrose oil.


Assuntos
Antieméticos/uso terapêutico , Terapias Complementares/métodos , Náusea/terapia , Fitoterapia/métodos , Preparações de Plantas/uso terapêutico , Pré-Eclâmpsia/terapia , Vômito/prevenção & controle , Ensaios Clínicos como Assunto , Terapias Complementares/efeitos adversos , Feminino , Zingiber officinale , Humanos , Disseminação de Informação , Início do Trabalho de Parto/efeitos dos fármacos , Mães/psicologia , Náusea/prevenção & controle , Percepção , Fitoterapia/efeitos adversos , Extratos Vegetais/uso terapêutico , Pré-Eclâmpsia/prevenção & controle , Gravidez , Complicações na Gravidez/tratamento farmacológico , Prevalência , Ensaios Clínicos Controlados Aleatórios como Assunto
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