RESUMO
In patients undergoing plastic surgery, donor sites were treated with soft pads of freeze-dried N-carboxybutyl chitosan to promote ordered tissue regeneration. Compared to control donor sites, better histoarchitectural order, better vascularization and the absence of inflammatory cells were observed at the dermal level, whilst fewer aspects of proliferation of the malpighian layer were reported at the epidermal level. Accordingly, N-carboxybutyl chitosan leads to formation of regularly organized cutaneous tissue and reduces anomalous healing.
Assuntos
Curativos Biológicos , Quitina/análogos & derivados , Quitosana , Transplante de Pele/métodos , Pele/ultraestrutura , Cirurgia Plástica/métodos , Cicatrização/fisiologia , Adulto , Colágeno/ultraestrutura , Feminino , Fibroblastos/ultraestrutura , Humanos , Masculino , Microscopia Eletrônica , Pessoa de Meia-Idade , Transplante de Pele/fisiologia , Coxa da PernaRESUMO
Expanders coated with N-carboxybutyl chitosan were inserted into surgical wounds in the dorsal skin of rabbits and the formation of capsular tissue was studied by scanning electron microscopy and transmission electron microscopy. N-carboxybutyl chitosan, in the course of the capsular organization, favours and potentiates the correct proliferation and organization of the tissue, rather than sustaining reactive processes leading to scar formation. N-carboxybutyl chitosan stimulates physiologically the tissue repair process and favours angiogenesis, whilst depressing fibrogenesis to a certain extent. Applications are envisaged in the treatment of wounds and in plastic surgery.
Assuntos
Materiais Biocompatíveis , Quitina/análogos & derivados , Quitosana , Dispositivos para Expansão de Tecidos , Animais , Colágeno/análise , Citoplasma/ultraestrutura , Fibroblastos/ultraestrutura , Microscopia Eletrônica de Varredura , Neovascularização Patológica , Organelas/ultraestrutura , Coelhos , Pele/irrigação sanguíneaRESUMO
Many current techniques for vulval reconstruction following cancer excision satisfy the basic requirements for restoration of urinary and sexual function but leave considerable scars on the thigh. We suggest the use of bilateral island groin flaps, which allow a good cosmetic and functional reconstruction with a minimal donor defect and more acceptable scars. This technique also allows good access to the inguinal, crural and iliac lymph nodes through the same incisions, avoiding other scars.
