RESUMO
Hepatitis B virus (HBV), Hepatitis C virus (HCV), and Hepatitis E Virus (HEV) are highly endemic in several African countries including Nigeria with adverse effects on pregnancy outcomes resulting in fatality. This study aimed to determine the viral hepatitis in pregnant women attending antenatal clinic, AMTHI. Informed consent questionnaire was administered before blood collection via venipuncture. a total of 904 pregnant women plasma samples were tested for HBV, HCV, and HEV using ELISA kit. Data was analyzed using packages within SPSS software and P ≤ 0.05 was considered significant. Out of 904 samples analyzed, the overall prevalence of hepatitis infections among pregnant women attending antenatal clinic in AMTHI was 66(7.3%). High prevalence of the hepatitis infections was found among young women within the age group 21-30 which might be associated with active sex, intravenous drug use, sharing of sharp objects and alcoholism. Blood group O Positive had the highest prevalence of hepatitis. There was statistical significance between blood group and HBsAg infection (P < .05). Genotype AA women had highest prevalence of hepatitis. This study showed significant association between HBsAg, HCV, and HEV positive status with blood group O positive and Genotype AA pregnant women.
Assuntos
Hepacivirus/isolamento & purificação , Antígenos de Superfície da Hepatite B/sangue , Vírus da Hepatite B/isolamento & purificação , Vírus da Hepatite E/isolamento & purificação , Hepatite Viral Humana/epidemiologia , Hepatite Viral Humana/virologia , Complicações na Gravidez/epidemiologia , Complicações na Gravidez/virologia , Sistema ABO de Grupos Sanguíneos/genética , Adolescente , Adulto , Criança , Ensaio de Imunoadsorção Enzimática , Feminino , Genótipo , Hepatite Viral Humana/sangue , Hepatite Viral Humana/genética , Hospitais de Ensino , Humanos , Imunoglobulina M/sangue , Nigéria/epidemiologia , Gravidez , Complicações na Gravidez/sangue , Complicações na Gravidez/genética , Prevalência , Adulto JovemRESUMO
Pulmonary alveolar proteinosis is a rare disease characterized by the deposit of lipid-rich proteinaceous material in alveolar spaces. The only effective treatment known to date has been periodic alveolar lavage, a technique that is laborious and requires that the patient be under general anesthesia, with selective endotracheal-bronchial intubation. Complications are not unknown. Progress in our understandint of the pathogenesis of pulmonary alveolar proteinosis has shown it to be related to changes it to be related to changes in alveolar macrophagocytic capability. We describe a patient in whom 8 weeks of subdermal GM-CSF treatment led to significant clinical, radiologic and lung function improvement.
Assuntos
Fator Estimulador de Colônias de Granulócitos e Macrófagos/uso terapêutico , Proteinose Alveolar Pulmonar/tratamento farmacológico , Adulto , Líquido da Lavagem Broncoalveolar , Fator Estimulador de Colônias de Granulócitos e Macrófagos/administração & dosagem , Humanos , Injeções Subcutâneas , MasculinoRESUMO
Aplastic anemia secondary to infection by parvovirus B19 is normally an extremely rare problem in patients with no prior history. However, the presence of certain risks, such as receiving chronic immunosuppressant therapy, may facilitate its appearance. Very few cases have been published concerning red cell aplasia due to parvovirus B19 infection in patients receiving a transplanted lung. We report the case of a 24-year-old woman with cystic fibrosis who had received a double lung transplant. The patient developed red cell aplasia secondary to parvovirus B19 infection; severe anemia requiring multiple transfusions. Five days of intravenous immunoglobulin therapy resolved the anemia. We discuss the difficulty of serological diagnosis in such cases, the importance of using techniques that identify the virus and taking measures that may prevent recurrence.
Assuntos
Transplante de Pulmão , Infecções por Parvoviridae/complicações , Complicações Pós-Operatórias , Aplasia Pura de Série Vermelha/etiologia , Adulto , Transfusão de Sangue , Fibrose Cística/cirurgia , Feminino , Seguimentos , Humanos , Imunoglobulinas Intravenosas/administração & dosagem , Transplante de Pulmão/efeitos adversos , Aplasia Pura de Série Vermelha/diagnóstico , Aplasia Pura de Série Vermelha/terapia , Fatores de TempoRESUMO
La anemia aplásica aguda secundaria a la infección por Parvovirus B19 suele ser un problema extremadamente raro en sujetos sin patología previa. Sin embargo, la existencia de determinadas situaciones de riesgo, como recibir terapia inmunosupresora de forma crónica, puede facilitar su aparición. Son muy escasos los casos que se han publicado hasta el momento de aplasia de células rojas debido a infección por Parvovirus B19 en pacientes sometidos a trasplante pulmonar. Se presenta el caso de una mujer de 24 años de edad trasplantada bipulmonar por una fibrosis quística, que desarrolló una aplasia de células rojas, condicionante de una anemia grave que requirió transfusiones múltiples, secundaria a una infección aguda por Parvovirus B19. Un tratamiento con inmunoglobulinas intravenosas durante 5 días permitió la resolución de la anemia. Se discute la dificultad del diagnóstico serológico en estos casos y la importancia del uso de las técnicas de identificación viral para lograrlo, y se argumentan las posibles medidas preventivas para evitar su recurrencia (AU)
Assuntos
Adulto , Feminino , Humanos , Transplante de Pulmão , Complicações Pós-Operatórias , Fatores de Tempo , Imunoglobulinas Intravenosas , Infecções por Parvoviridae , Aplasia Pura de Série Vermelha , Transfusão de Sangue , Fibrose Cística , SeguimentosRESUMO
The first case of malignant schwannoma of the submandibular gland in a 23-year-old man with neurofibromatosis is reported. Light microscopy showed typical features of neurogenic sarcoma and an immunocytochemical study confirmed the schwannian differentiation of the neoplasm. The patient is still well without evidence of metastases or local recurrence of the tumor 80 months after the excision of the neoplasm.
