Modification of experimental liver damage by an antiseptic: alkyldimethylbenzylammonium chloride.

Effect of Roccal (alkyldimethylbenzylammonium chloride) applications on the progress of liver recovery after damaging it by oral introduction of carbon tetrachloride (CCl4) to adult nonline rats twice a week during a month at the dosage of 0.1 ml/100 g of 50% oil solution was investigated. The Roccal applications at the dosage 10 mg/kg (1/50 DL50 skin) during a month 5 times a week intensify the functional and morphological liver damage, slows down the recovery, provokes earlier nephrotoxic effect, modifies the changes of nitrogen balance. The other phenomena of the toxic hepatopathy and the resorbtive effect of Roccal were manifested on the subcellular level by the intracellular liver hypertrophy, the damage of glycerophosphatic mitochondrial shunt, the increase of catabolism, probably the accumulation of the peroxidated products in the blood leukocytes. The changes of the leukocytes enzymatic status were aggravated by the influence of Roccal during the recovering process of the experimental hepatopathy.

[Experimental study of the aftereffects of feeding rats certain types of canned fish]. / Izuchenie v éksperimente posledstvii skarmlivaniia krysam nekotorykh vidov rybnykh konservov.

For 3 years fish canned goods were added to the ration of rats. These additions included atlantic herring in tomato gravy ("Stavrida"), dressed sprat in tomato gravy (sprats-small-sized) or sprat in vegetable oil ("Sprat"). Rats receiving canned "small-sized sprats" or "sprats developed much more often malignant tumors of different localization than did the animals fed on "Stavrida" or control rats. Feeding of rats on the vegetable oil from "stavrida" and "sprat" cans did not have any material effect on the development of tumours. Introduction of these samples of oil together with the food or parenterally to mice did not have any substantial influence on the development in them of skin tumors, induced with benzpyrene. The canned goods under investigation, especially of the "sprat" kinds, demonstrated small amounts of benzpyrene and carcinogenic nitroso-compounds.