An aggressive course of de novo ulcerative colitis after renal transplantation: colonic adenocarcinoma with choriocarcinomatous differentiation.

AIM: A rare case of colonic carcinoma arising in de novo ulcerative colitis after renal transplantation in a 42-year-old woman is reported. CASE: Clinically, the patient presented ulcerative colitis 8 years after renal transplantation, developed colonic cancer with liver metastasis 2 years later and died one month post operatively. Histologically, the removed tumor was composed of two distinctive elements consisting of adenocarcinoma and choriocarcinoma. The metastatic foci in the liver were composed exclusively of choriocarcinoma. Identification as choriocarcinoma was made on the basis of typical histological appearance, immunohistochemical demonstration of human chorionic gonadotropin (hCG) in the tumor cells and the high serum hCG level, unrelated to trophoblastic disease. In this report, pathogenesis is briefly discussed and clinical conditions are reviewed. CONCLUSION: In conclusion, the issue of de novo UC after organ transplantation is still a matter of debate. Further investigations are necessary to understand the tumorogenesis of colorectal cancer in de novo UC after renal transplantation,

[Abdominal desmoid tumor: pathologic and therapeutic concepts]. / Tumeur desmoide abdominale: concepts histopathologiques et therapeutiques.

BACKGROUND: Abdominal desmoid tumors arise in young adults between 20 and 40 years. They are characterized by a local recurrence in 20 to 30% of cases. AIM: review the clinical and pathologic features of this entity, look for the expression of immunohistochemical markers (actine, desmine, CD34, vimentin) and also to estimate the expression of two potential targets therapy; the hormonal receptors and the CD117. METHODS: From 1990 to 2004, three cases of abdominal desmoid tumors were diagnosed in the Pathologic laboratory of the Charles Nicole Hospital of Tunis. RESULTS: The study concerned three women 62, 35 and 30 year-old. All the patients were operated and the size of tumours varied to 5 to 7cm. The CD117 and the hormonal receptors were negative in every case. None of the patients presented local recurrence. CONCLUSION: Abdominal desmoid tumors are locally aggressive but never give metastasis. The negativity of these lesions to the CD117 and in the hormonal receptors does not imply resistance in the hormonal treatment by anti-estrogens.

[Contribution of immunohistochemical detection of human herpesvirus-8 latent nuclear antigen-1 in the diagnosis of Kaposi disease]. / Apport de la détection immunohistochimique de l'antigène nucléaire de latence 1 de l'herpes virus humain 8 dans le diagnostic de la maladie de Kaposi.

AIMS: To study the immunohistochemical expression of HHV8 in Kaposi's lesions and in other vascular lesions and to determine the utility of this technique in differentiating between Kaposi's disease (KD) and other vascular lesions. METHODS: Fixed, paraffin-embedded tissue sections from 25 cases of KD, 9 cases of hemangioma, 2 cases of angiolymphoid hyperplasia with eosinophilia and 9 cases of angiosarcoma were examined immunohistochemically using the monoclonal antibody monoclonal LNA 53 (ABI). Strong, nuclear and granular staining in at least a cell was considered as a positive result. RESULTS: Sixteen cases of KD showed positive staining, whereas all cases of hemangioma, angiolymphoid hyperplasia with eosinophilia and angiosarcoma were negative for this antigen CONCLUSION: Immunohistochemical detection of the human herpesvirus-8 latent nuclear antigen-1 is a useful for differentiating between KD and other vascular lesions.

[Retroperitoneal Castleman disease]. / Maladie de Castleman rétropéritonéale.

Castleman disease or angiofollicular lymph node hyperplasia is a rare disease of unknown cause with polymorphic clinical features that raises many diagnostic and therapeutic problems. The unifocal, localized, pseudoneoplastic form, first described in 1956, has a good prognosis, but the multifocal form has a more aggressive course. Three histological types have been identified: hyaline vascular, plasma cell and mixed. The authors present a case of hyaline vascular unifocal Castleman disease. A retroperitoneal mass was discovered incidentally during follow-up ultrasound examination in a 38-year-old woman treated for recurrent renal stones. On CT examination, a solid mass measuring 9 x 8 x 6 cm raised a problem of differential diagnosis with other retroperitoneal masses. CT-guided biopsy was inconclusive and the diagnosis was finally established by tumour excision and histological examination. The immediate and subsequent postoperative course was uneventful.