Manufacturing methods, properties, and potential applications in bone tissue regeneration of hydroxyapatite-chitosan biocomposites: A review.

Hydroxyapatite (HA) and chitosan (CS) biopolymer are the major materials investigated for biomedical purposes. Both of these components play an important role in the orthopedic field as bone substitutes or drug release systems. Used separately, the hydroxyapatite is quite fragile, while CS mechanical strength is very weak. Therefore, a combination of HA and CS polymer is used, which provides excellent mechanical performance with high biocompatibility and biomimetic capacity. Moreover, the porous structure and reactivity of the hydroxyapatite-chitosan (HA-CS) composite allow their application not only as a bone repair but also as a drug delivery system providing controlled drug release directly to the bone site. These features make biomimetic HA-CS composite a subject of interest for many researchers. Through this review, we provide the important recent achievements in the development of HA-CS composites, focusing on manufacturing techniques, conventional and novel three-dimensional bioprinting technology, and physicochemical and biological properties. The drug delivery properties and the most relevant biomedical applications of the HA-CS composite scaffolds are also presented. Finally, alternative approaches are proposed to develop HA composites with the aim to improve their physicochemical, mechanical, and biological properties.

Sustainable phosphorylated microcrystalline cellulose toward enhanced removal performance of methylene blue.

In this study, microcrystalline cellulose (MCC) was phosphorylated using phosphoric acid in the presence of urea and used as an adsorbent for methylene blue (MB) dye removal from an aqueous solution. The obtained products were characterized by different techniques. Batch adsorption experiments were conducted under varying conditions of incubation time, initial MB concentration, pH, and phosphorylation degree. All the samples exhibited similar and fast adsorption kinetics, described by pseudo-second-order model for MB adsorption, whereas the retention capacity depended significantly on the phosphate content and the surface charge of the adsorbents. The experimental adsorption data in the examined MB initial concentrations (0-2000 mg/L) were best suited by the Langmuir isotherm model. The study revealed that the presence of phosphates groups in the cellulose structure significantly enhanced the adsorption of the MB pollutant. The maximum dye removal capacity at pH of 7 was obtained for the phosphorylated microcrystalline cellulose (284.03 mg/g) with a high phosphorylation degree (1.92 % of P), which is 20 times higher than unmodified MCC (15.29 mg/g). This property increased from 284.03 to 328.32 mg/g when increasing the pH from 7 to 11. The MB adsorption mechanism involves hydrogen bonding, electrostatic and ion-dipole interactions. These findings are relevant to a better understanding of the role of cellulose phosphorylation in the recovery of organic dyes from the waste liquid of many industries.

New highly hydrated cellulose microfibrils with a tendril helical morphology extracted from agro-waste material: application to removal of dyes from waste water.

Cocoa bean shells (CBS) are a by-product of the cocoa bean processing industry. They represent 12-20 wt% of dry cocoa beans, after having been separated from these by a roasting process. CBS often end up as a waste product which contains around 34 wt% of cellulose. The transformation of this waste into valuable and marketable products would help to improve waste disposal. Indeed, the large annual production of this waste makes it a sustainable and renewable bio-source for the production of chemicals and fibers for advanced applications. In this work, new cellulose microfibrils (CMFs) with a tendril helical morphology and highly hydrated gel-like behavior were successfully extracted from CBS waste using a controlled chemical extraction process. During this study, several physico-chemical characterizations were carried out in order to identify the properties of each of the products at different stages of treatment. Microscopic observations show that the extracted CMFs have a tendril helical shape like climbing plant tendrils. Due to this special morphology, the extracted CMFs show a highly hydrated state forming a gel network without additional modifications. The as-extracted CMFs were used as adsorbent material for the removal of methylene blue from concentrated aqueous solution, as an application to wastewater treatment for the removal of basic dyes. Swelling properties, adsorption kinetics and isotherms were carried out in batch experiments. The results indicated that the CMFs have a high swelling capacity (190%). The pseudo second order model can be effectively used to evaluate the adsorption kinetics and the adsorption isotherms can also be described well by the Langmuir isotherm model with a maximum adsorption capacity of 381.68 mg g-1. Thus, the as-extracted CMFs with unique characteristics have the potential to be used as efficient adsorbent material for the removal of different cationic dyes from industrial wastewater.