Potentially toxic elements in the environment - a review of sources, sinks, pathways and mitigation measures.

Pollution of ecosystems with potentially toxic elements (PTEs) has become a global problem with serious consequences for public health. The PTEs are hazardous to humans owing to their longevity, toxicity, and ability to accumulate in the biotic environment. As most PTEs cannot be degraded microbially or chemically, they can persist in soils for a long time. Besides posing a threat to landsphere, they may be transported to surrounding environmental spheres through movement of water, atmospheric circulation, and biological transmission. This can severely affect the ecological equilibrium. Accumulation of PTEs in soils pose serious health hazards to higher organisms leading to various diseases and disorders and significant relationships exist between the occurrence of PTEs and the toxic effects in humans. In natural soils, PTEs accumulate due to weathering of rocks and ores. Furthermore, locally or regionally significant accumulation of PTEs in soils may occur from industrial goods, pesticides and paints, municipal and industrial waste, fertilizer application, mining activities and atmospheric deposition. In response to the growing need to address PTE contamination, remediation methods have been developed employing mechanical, physico-chemical or biological based technologies. In this review, we discuss sources, sinks, pathways and mitigation measures related to natural and anthropogenic PTEs. We focus on As, Cd, Cr, Hg and Pb which are highly toxic and perform no physiological functions in biota. Further, these are the most widely studied PTEs.

Reactive nitrogen compounds and their influence on human health: an overview.

Nitrogen (N) is a critical component of food security, economy and planetary health. Human production of reactive nitrogen (Nr) via Haber-Bosch process and cultivation-induced biological N2 fixation (BNF) has doubled global N cycling over the last century. The most important beneficial effect of Nr is augmenting global food supplies due to increased crop yields. However, increased circulation of Nr in the environment is responsible for serious human health effects such as methemoglobinemia ("blue baby syndrome") and eutrophication of coastal and inland waters. Furthermore, ammonia (NH3) emission mainly from farming and animal husbandary impacts not only human health causing chronic lung disease, inflammation of human airways and irritation of eyes, sinuses and skin but is also involved in the formation of secondary particulate matter (PM) that plays a critical role in environment and human health. Nr also affects human health via global warming, depletion of stratospheric ozone layer resulting in greater intensity of ultra violet B rays (UVB) on the Earth's surface, and creation of ground-level ozone (through reaction of NO2 with O2). The consequential indirect human health effects of Nr include the spread of vector-borne pathogens, increased incidence of skin cancer, development of cataracts, and serious respiratory diseases, besides land degradation. Evidently, the strategies to reduce Nr and mitigate adverse environmental and human health impacts include plugging pathways of nitrogen transport and loss through runoff, leaching and emissions of NH3, nitrogen oxides (NO x ), and other N compounds; improving fertilizer N use efficiency; reducing regional disparity in access to N fertilizers; enhancing BNF to decrease dependence on chemical fertilizers; replacing animal-based proteins with plant-based proteins; adopting improved methods of livestock raising and manure management; reducing air pollution and secondary PM formation; and subjecting industrial and vehicular NO x emission to pollution control laws. Strategic implementation of all these presents a major challenge across the fields of agriculture, ecology and public health. Recent observations on the reduction of air pollution in the COVID-19 lockdown period in several world regions provide an insight into the achievability of long-term air quality improvement. In this review, we focus on complex relationships between Nr and human health, highlighting a wide range of beneficial and detrimental effects.

Integrated review of the nexus between toxic elements in the environment and human health.

Emerging pollutants in the environment due to economic development have become a global challenge for environmental and human health management. Potentially toxic elements (PTEs), a major group of pollutants, have been detected in soil, air, water and food crops. Humans are exposed to PTEs through soil ingestion, consumption of water, uptake of food crop products originating from polluted fields, breathing of dust and fumes, and direct contact of the skin with contaminated soil and water. The dose absorbed by humans, the exposure route and the duration (i.e., acute or chronic) determine the toxicity of PTEs. Poisoning by PTEs can lead to excessive damage to health as a consequence of oxidative stress produced by the formation of free radicals and, as a consequence, to various disorders. The toxicity of certain organs includes neurotoxicity, nephrotoxicity, hepatotoxicity, skin toxicity, and cardiovascular toxicity. In the treatment of PTE toxicity, synthetic chelating agents and symptomatic supportive procedures have been conventionally used. In addition, there are new insights concerning natural products which may be a powerful option to treat several adverse consequences. Health policy implications need to include monitoring air, water, soil, food products, and individuals at risk, as well as environmental manipulation of soil, water, and sewage. The overall goal of this review is to present an integrated view of human exposure, risk assessment, clinical effects, as well as therapy, including new treatment options, related to highly toxic PTEs.