Preference and the specificity of goals.

In this study, the authors examined (a) the effect of changes in the need to eat on expressed preferences for foods that are appropriate for different times of day and (b) whether that need is directed toward food in general or foods contextually appropriate to the time of day. Previous findings suggest that, when the goal is active relative to when it is inactive, items relevant to satisfying a goal increase in value but items unrelated to that goal decrease in value. The authors observed that, when people needed to eat, they sought foods that are contextually appropriate to the time of day of the study. Hence, the goal they sought to fulfill was narrower than seeking foods in general.

Increased prevalence of and gene transcription by Chlamydia pneumoniae in cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis.

Microbial agents may play a role in the pathogenesis of multiple sclerosis (MS). C. pneumoniae has been recently associated with MS; however, study results are at variance. We tested the hypothesis that Chlamydia pneumoniae-specific DNA and RNA are more often detected in cerebrospinal fluid (CSF) of patients with multiple sclerosis than patients with other neurological diseases (OND). We investigated CSF samples from 84 patients with definite MS and 89 OND patients (n = 62 with normal CSF; n = 27 with pathological CSF) using a nested polymerase chain reaction (PCR) to detect ompA gene sequences of C. pneumoniae. In subjects with positive PCR, we probed for chlamydial heat shock protein 60-mRNA and 16S-rRNA by reverse transcriptase (rt)-PCR. C. pneumoniae-specific DNA was more often detected in MS patients (50 %) than in all OND patients combined (28.1%, p = 0.003) and in OND patients with normal CSF (24.2%, p = 0.003) but not than in OND patients with pathological CSF (37%, p = 0.24). In relapsing-remitting MS (n = 55), the prevalence of C. pneumoniae DNA was higher (66.7 %) than in both OND subgroups (p

Evidence for infection with Chlamydia pneumoniae in a subgroup of patients with multiple sclerosis.

In a pilot study, we identified Chlamydia pneumoniae in the cerebrospinal fluid by polymerase chain reaction in 5 of 10 patients with definite multiple sclerosis (MS). In a second series, 2 of 20 patients with definite MS and 3 of 17 patients with possible/probable MS or MS variants, but none of 56 patients with other neurological, diseases were polymerase chain reaction-positive. We confirm that C. pneumoniae can be found in the cerebrospinal fluid of MS patients, but our rate of positive results is lower than in a recent report.

Widespread Cutaneous Reactions: A spectrum of disease.

The three cutaneous reaction patterns of erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis share many clinical features. Each is multifactorial in etiology; together they account for most severe cutaneous drug eruptions. In some respects, they can represent a progression in the severity of drug eruptions. Controversy continues to cloud the clinical delineation, etiology, and treatment.