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Sci Rep ; 11(1): 13860, 2021 07 05.
Artigo em Inglês | MEDLINE | ID: mdl-34226649

RESUMO

Covid-19 epidemic dramatically relaunched the importance of mathematical modelling in supporting governments decisions to slow down the disease propagation. On the other hand, it remains a challenging task for mathematical modelling. The interplay between different models could be a key element in the modelling strategies. Here we propose a continuous space-time non-linear probabilistic model from which we can derive many of the existing models both deterministic and stochastic as for example SI, SIR, SIR stochastic, continuous-time stochastic models, discrete stochastic models, Fisher-Kolmogorov model. A partial analogy with the statistical interpretation of quantum mechanics provides an interpretation of the model. Epidemic forecasting is one of its possible applications; in principle, the model can be used in order to locate those regions of space where the infection probability is going to increase. The connection between non-linear probabilistic and non-linear deterministic models is analyzed. In particular, it is shown that the Fisher-Kolmogorov equation is connected to linear probabilistic models. On the other hand, a generalized version of the Fisher-Kolmogorov equation is derived from the non-linear probabilistic model and is shown to be characterized by a non-homogeneous time-dependent diffusion coefficient (anomalous diffusion) which encodes information about the non-linearity of the probabilistic model.


Assuntos
Algoritmos , COVID-19/epidemiologia , Modelos Estatísticos , SARS-CoV-2/patogenicidade , Simulação por Computador , Humanos , Modelos Biológicos , Modelos Teóricos , Processos Estocásticos
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