[Features of the course and adverse events risk of coronavirus infection COVID-19 in hematological diseases (data from the CHRONOS19 register for the Primorsky Territory, intermediate stage)].

AIM: To assess the characteristics of the course of coronavirus infection COVID-19 and to determine the risk factors for adverse events in patients of the regional hematological center. MATERIALS AND METHODS: As part of an observational prospective cohort study, data from 144 medical records of patients in Primorsky Krai with hematological diseases and COVID-19 were analyzed. The data of the developed standardized questionnaire of the CHRONOS19 study were used. The primary endpoint (adverse outcome) was a composite point that included mortality from any cause during the observation period, development of acute respiratory distress syndrome, hospitalization in the intensive care unit, and the need for mechanical ventilation. RESULTS: A study of the features of the course of COVID-19 in hematological patients showed an increase in the number of adverse events in patients with neoplastic blood diseases, especially in chronic lymphoproliferative diseases and acute myeloid leukemia. Significant predictors of an unfavorable course of COVID-19 include a refractory/recurrent variant of the course of a blood tumor, glucocorticoid therapy as part of the protocol for the treatment of the underlying disease, stage 3-4 lung damage according to computerised tomography scans at the onset of COVID-19, and the presence of diabetes mellitus. CONCLUSION: Predictors of an unfavorable course of COVID-19 in hematological patients have been identified. Hematological patients in the context of the COVID-19 pandemic require a coordinated interdisciplinary approach involving hematologists and therapists, careful monitoring of clinical and laboratory parameters to reduce the risk of adverse events.

Assessing the level of matrix metal proteinases 1,8,9, their tissue inhibitor, type I, in cases of odontogenic phlegmons.

The article considers the measured values of the level of MMP-1, MMP-8 and MMP-9, and of their tissue inhibitor Type I (TIMP-1) in the blood serum and mixed saliva samples of 78 patients (31 women - 36.2 %, 47 men - 63.8 %) suffering from odontogenic phlegmons in the oral and maxillofacial region. The study indicators were assessed through the enzyme-linked immunosorbent assay using diagnostic sets RandD Diagnostics Inc. (USA). An uncontrolled hyperactivation of metal proteinases as one of the components of the systemic inflammatory response in case of phlegmon-related complications in the oral and maxillofacial region, as well as development of the sepsis syndrome were studied and it was determined that it results in distortion of the processes of reparative hystogeny and compel us to employ new approaches to the treatment of this type of patients (Tab. 2, Fig. 1, Ref. 13).

[Specific clinical and immunological features of chronic diseases of the nasal-associated lymphoid tissue in the children].

The objective of the present work was to study the structure, clinical, and immunological features of various etiological variants of chronic diseases of the nasal-associated lymphoid tissue in the children. A total of 142 children at the age from 3 to 7 years presenting with this pathological condition were available for the observation. The study revealed differences in the clinical course of the disease and the cytokine response (IL-6, Ril-6, TNF, sYNFR55, sTNFR75) at the local and systemic levels for different pathogens (S. aureus, S. pneumoniae, S. pyrogenes).

[Chemical composition of breast milk in females with preterm deliveries in the Primorsky Krai].

In the article there are presented data on the chemical composition of breast milk in females with preterm labor in the Primorye Territory, who were in the Department of newborns for premature babies of the Municipal Institution of Health "Children's city clinical hospital" in Vladivostok during 2010-2011 to care for their newborn infants. Laboratory studies were performed in the Federal State Institution of Health "Center of Hygiene and Epidemiology in the Primorye Territory."

[Application of immunospecific drug in the treatment of rotavirus gastroenteritis in children].

The case records of 120 children older than 4 years with rotavirus infection have been studied. In this group, 22 patients received basic therapy and 98 received complex therapy with cycloferon. Appropriate therapy resulted in rapid positive dynamics of clinical symptoms, the disease outcomes have been improved. Cytokine reaction has been studied as dependent on the treatment method. Positive dynamics of clinical symptoms and cytokine level has been revealed in a group of children having received cycloferon. It is recommended to include cycloferon in the basic therapy of rotavirus diarrhea in children.

[Possibilities of adaptation and health status in children left without parental care].

The study was undertaken to examine the health status of abandoned infants in a sociomedical unit, by characterizing their adaptive capacities and by revealing the factors worsening the processes of adaptation. Adaptive impairments were found in the abandoned babies just at early age. Health status, constitutional type, development harmonicity, and a past parental medical history had a considerable impact on the child's adaptive capacities.

[Infectious mononucleosis: etiology, immunological variants, methods of correction].

Clinical options of infectious mononucleosis course depending on infecting agent etiology are presented for Epstein-Barr virus (EBV), cytomegalovirus (CMV), mono and mixed forms of the disease. Examined cytokine profiles demonstrate analogous changes of serum cytokines in the acute stage of the disease irrespective of etiological factors. Data show that it is important and useful clinically and immunologically to include immunomodulators--in particular, cycloferon--info a complex therapy of different types of mononucleosis.

[Staged treatment and follow-up of patients with yersinia infections]. / Etapnoe lechenie i dispanserizatsiia bol'nykh iersiniozami.

Basing on the data obtained on immunopathogenetic and lipid metabolism features of intestinal yersiniosis and pseudotuberculosis in children, the authors offer variants of etiotropic and pathogenetic treatment specific for certain stages of the above diseases which are able to reduce the rate of aggravations, recurrences and complications by 10-12%. Long-term follow-up showed that unfavourable outcomes of yersiniosis are not infrequent this urging the necessity of 6-12-month follow-up of the convalescents.