RESUMO
Acute pancreatitis is not infrequent after allogenic marrow transplantation. Several causes can predispose to pancreatitis, including Graft-Versus-Host Disease (GVHD), a condition which is probably underestimated. In the literature, few description of pancreatic GVHD can be found. Pancreatic GVHD diagnosis can be difficult if pancreatic involvement occurs without other typical manifestations of GVHD. We report the case of a woman, 54 years old, suffering from prolonged, painful pancreatitis two months after allogenic bone marrow transplantation for acute myeloid leucemia. Pancreatic GVHD diagnosis was performed after five weeks on duodenal biopsies despite the absence of diarrheoa. The patient dramatically improved within few days on corticosteroids.
Assuntos
Transplante de Medula Óssea/efeitos adversos , Pancreatite/etiologia , Doença Aguda , Feminino , Humanos , Pessoa de Meia-Idade , Fatores de TempoRESUMO
We report the case of a 23-year-old woman who presented with an adult form of metachromatic leukodystrophy (MLD) evolving over one year with a progressive neurological deterioration. A non-myeloablative matched related haematopoietic stem cell transplantation (HSCT) with concomitant mesenchymal stromal cells (MSCs) infusion was performed. Engraftment occurred rapidly with no significant toxicity or side effects following the MSC infusion. At a follow up of 40 months, the patient had a stabilisation of all neurological manifestations of her disease. This case report suggests the feasibility and the potential efficacy of reduced intensity conditioning (RIC) allogeneic HSCT combined with MSC infusion for patients with the adult form of MLD.
Assuntos
Transplante de Células-Tronco Hematopoéticas/métodos , Leucodistrofia Metacromática/sangue , Leucodistrofia Metacromática/terapia , Mesoderma/metabolismo , Células Estromais/citologia , Células Estromais/patologia , Condicionamento Pré-Transplante/métodos , Adulto , Células da Medula Óssea/citologia , Transplante de Medula Óssea , Cerebrosídeo Sulfatase/biossíntese , Feminino , Sobrevivência de Enxerto , Humanos , Imageamento por Ressonância Magnética , Resultado do TratamentoAssuntos
Leucemia Mieloide/cirurgia , Transplante de Células-Tronco de Sangue Periférico , Mielofibrose Primária/cirurgia , Doença Aguda , Anemia Refratária/tratamento farmacológico , Anemia Refratária/etiologia , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Terapia Combinada , Citarabina/administração & dosagem , Eritropoetina/uso terapêutico , Etoposídeo/administração & dosagem , Seguimentos , Fator Estimulador de Colônias de Granulócitos/uso terapêutico , Humanos , Leucemia Mieloide/tratamento farmacológico , Leucemia Mieloide/patologia , Masculino , Metotrexato/administração & dosagem , Pessoa de Meia-Idade , Mitoxantrona/administração & dosagem , Complicações Pós-Operatórias/tratamento farmacológico , Complicações Pós-Operatórias/etiologia , Mielofibrose Primária/tratamento farmacológico , Mielofibrose Primária/patologia , Proteínas Recombinantes , Condicionamento Pré-Transplante/efeitos adversos , Transplante Autólogo , Irradiação Corporal Total/efeitos adversosRESUMO
A 43-year-old female with large T-cell non-Hodgkin's lymphoma and central nervous system (CNS) involvement underwent HLA-identical-sibling peripheral blood stem cell transplantation (SCT) during her third complete remission. She presented a possible refractory CNS relapse 5 months after the transplant. She was then treated with intrathecal (IT) donor lymphocyte infusions (DLI). No side effects were observed after three DLI injections. The patient died 13 months later from infectious complications with no evidence of progressive disease. To our knowledge, this is the first case report of IT DLI for possible refractory lymphomatous meningitis.
