[Survival of patients with AIDS treated with protease inhibitors]. / Supervivencia de pacientes con SIDA tratados con inhibidores de la proteasa.

OBJECTIVE: Make a volarization of the effect on survival of the protease inhibitors used on patients with established-AIDS. METHODS: Retrospective study on patients diagnosed of AIDS between January 1989 and March 1998. The main objective is the time between diagnosis and dead. It is compared the survival curve of the patients on treatment with protease inhibitors (PI) with the ones without them. We use the methods of Kaplan-Meier and log-rank. RESULTS: We analyzed 99 patients diagnosed of AIDS. Fifteen were treated with PI in combination and eighty-four with regimens without them. The number of CD4 and the age at the beginning of the study, the type of transmission and the gender were similar at the two groups. The median survival of the treated with PI was 47 (4 months (CI 95%: 39-55), and the one of the no treated as 26(3 months (CI 95%: 20-32) (p = 0.0027) CONCLUSIONS: The treatment with Protease inhibitors plus other antiviral medications is associated with a survival prolongation in patients with AIDS.

Supervivencia de pacientes con SIDA tratados con inhibidores de la proteasa / Survival of patients with aids on treatment with protease inhibitors

Objetivo: Determinar el efecto del tratamiento con inhibidores de la proteasa (IP) en combinación con otros antirretrovirales sobre la supervivencia de los pacientes con SIDA establecido. Métodos: Estudio retrospectivo de pacientes diagnosticados de SIDA entre Enero de 1989 y Marzo de 1998. Se analiza el tiempo transcurrido desde el diagnóstico de SIDA hasta el fallecimiento. Se compara la curva de supervivencia de los pacientes que han recibido IP en su régimen terapéutico con las de los que no incluían IP en su tratamiento. Se utilizan los métodos de Kaplan-Meier y log-rank. Resultados: Se analizan 99 pacientes diagnosticados de SIDA. Quince fueron tratados con IP en combinación y 84 con regímenes que no incluían IP. El número de CD4 y la edad al inicio del estudio, la categoría de transmisión y el sexo fue similar en los dos grupos. La supervivencia media de los tratados con IP fue de 47 (4 meses (CI 95%: 39-55), y la de los no tratados de 26(3 meses (CI 95%: 20-32) (p=0.0027). Conclusiones: El tratamiento con inhibidores de la Proteasa en combinación con otros antirretrovirales se asocia a una prolongación de la supervivencia de los pacientes con SIDA (AU)

[Impact of HIV infection in hospital environment]. / Impacto de la infección por VIH en el medio hospitalario.

OBJECTIVE: Retrospective study to review the admissions at the Hospital Marina Alta due to infection for HIV or its complications and look for risk factors. METHODS: Clinical charts of patients admitted at the hospital from 1989 to 1996 were analyzed. RESULTS: From 11,932 admissions, 199 (1.7%) were due to patients with infection from HIV, resulting in the 2.4% of the total stay. The medium stays were higher (8.6 +/- 7.4 vs 6 +/- 4.5) more re-admissions (42.7% vs 25.5%) and higher mortality (11% vs 7.8%). The parasitic infestations of the nervous central system and cardiovascular were the most numerous number of admissions and also the longer stays. Throughout the years we saw a increase in the patients at the outpatient clinic with HIV infection and a paradogic decrease in the inpatient admissions, and also a decrease in the media stay and total stays. CONCLUSIONS: There is a decrease in the admissions at the inpatient level in contrast with a increment of the prevalence in the outpatients with HIV infection. The improved treatments, the experience of the physicians, the use of the Day Hospital and the use of the service of Home Care Hospitalization allows to keep more patients with less admissions and more outpatient visits.