[Dynamics of the plasma fibronectin level in patients with food poisoning]. / Dinamika urovnia plazmennogo fibronektina u bol'nykh s pishchevymi toksikoinfektsiiami.

A study was made of the influence of the level and biological activity of plasma fibronectin of phagocytosis and opsonic activity of blood plasma in 147 patients with food toxinfections depending on a period and degree of severity of a course of disease. Plasma fibronectin concentration was determined by rocket immunoelectrophoresis. Fibronectin biological activity was assessed by cold heparin precipitation. Opsonic activity of blood plasma before and after fibronectin inactivation in it was investigated using indices of phagocytosis which was studied by optical microscopy. Food toxinfections were attended by a decrease in the level and biological activity of plasma fibronectin returning to normal during therapy and convalescence. A degree of the reduction of the level of plasma fibronectin reflected the severity of a course of food toxinfections. Phagocytic insufficiency developed in food toxinfections. One of its mechanisms was a decrease in opsonic activity of plasma fibronectin as a result of the reduction of its level.

[Quantitative characteristics of changes in the cellular composition and vascularization of aseptic wounds in rat skin, healing without treatment and during stimulation of repair processes by exogenous collagen]. / Kolichestvennaia kharakteristika izmeneniia kletochnogo sostava i vaskuliarizatsii asepticheskikh ran kozhi krys, zazhivaiushchikh bez lecheniia i pri stimuliatsii reparativnykh protsessov éksogennym kollagenom.

The changes in cellular composition and vascularization of aseptic wounds on the rat skin were assessed quantitatively using the ocular net without treatment and during stimulation of repair processes by exogenous collagen. An intensive increase in the number of macrophages, endotheliocytes and fibroblasts was observed in wounds without treatment by the fifth day, with maximum vascularization of the granulation tissue occurring by the seventh day. During stimulation of repair processes by collagen the macrophage reaction, proliferation of endotheliocytes and fibroblasts and vascularization of wounds were activated earlier, while the stereotype relationships of the cellular components remained unchanged. The intercellular relationships of the wound healing process are discussed.

[Treatment of suppurative wounds of soft tissues with colocyl and its combination with proteolytic enzymes]. / Lechenie gnoinykh ran miagkikh tkanei kolotsilom i ego sochetaniem s proteoliticheskimi fermentami.

The effect of a collagenous preparation Colocyl and its combination with proteolytic enzymes on the healing of soft tissue purulent wounds were studied in 239 patients. Colocyl and its combination with proteolytic enzymes were shown to facilitate the rejection of devitalized tissues, control of the inflammation and activation of reparative processes.

[Features of the healing of suppurative wounds in patients undergoing treatment with collagen preparations (histochemical and electron-microscopic study)]. / Osobennosti zazhivleniia gnoinykh ran u bol'nykh pri lechenii kollagenovymi preparatami (gistokhimicheskoe i élektronno-mikroskopicheskoe issledovanie).

The dynamics of purulent wound healing developing in patients surgically treated for phlegmons or abscesses was studied histochemically and electron microscopically on the material of successive biopsies. It was shown that purulent wound healing is characterized by the desynchronization of inflammation and regeneration associated with the reduced macrophagal response and disturbances of the microcirculation system. Collagen sponge reduces inflammatory changes, activates the macrophage reaction, restores intercellular interactions, normalizes the microcirculation system, enhances proliferation and differentiation of fibroblasts, collagen synthesis and secretion, processes of fibrillogenesis, maturation of granulation tissue, epithelialization.