[Non-neurogenic activators of myocyte contraction and their role in the realization of the accumulative-evacuating functions of the urinary bladder].

The search for and use of alternative biomarkers of the hyperactive bladder has garnered increasing attention in recent years because they may be considered pathogenetically significant and used as surrogate biomarkers. Promising agents that have met these criteria include proteins cytokines, neurotrophins, tumor necrosis factor (TNF), nerve growth factor (NGF), fibrinopeptides A and B, C-reactive protein, membrane-bound ATPase. Analysis of current scientific literature has demonstrated that specialists in many fields of medicine show interest in endogenous proteins that do not belong to neurotransmitters but affect the contractile ability of myocytes. The presented data indicate the feasibility and prospects of their use, but further studies and evaluation are needed. Based on the present literature review, the authors conclude that endogenous proteins activating myocyte contractility are of great clinical value as promising markers for detecting detrusor overactivity, its severity, and evaluation of the treatment effectiveness. The authors suggest that proteins of this group can play an important role not only in the pathogenesis of bladder function disorders but also in the physiological process of urination as an additional non-neurogenic humeral component.

Functional and metabolic changes in the brain in neuropathic pain syndrome against the background of chronic epidural electrostimulation of the spinal cord.

Changes in functional and metabolic activities of the brain were evaluated by EEG and positron-emission/computer tomography with 18F-fluorodeoxyglucose in patients with neuropathic pain syndrome previous to and 3 months after implantation of a system for chronic epidural spinal cord stimulation. In most cases, the use of a nerve stimulator was followed by alleviation of neuropathic pain and partial normalization of functional and metabolic activities of brain structures responsible for pain perception, emotiogenic, behavioral, and autonomic responses.

[Clinical-biochemical and immunological parameters in the diagnosis and treatment of chronic pyelonephritis on the background of intercurrent diseases].

Studies have shown that complicated chronic pyelonephritis in the active phase is characterized by structural and functional instability cytomembranes and decreased immunological resistance of the patient man. Supplement standard antibiotic treatment with ozone therapy antioxidant immunomodulation drug thus received immunobiochemical study.

[The diagnosis and treatment of common diseases detected during medical examination of male oil-extracting industry workers].

AIM: To study the health status of male shift workers engaged in oil-extracting industry in the Tyumen Region through prophylactic medical examination, to elaborate measures for the diagnosis and treatment of the most common diseases of the viscera and urogenital system (UGS). SUBJECTS AND METHODS: In 2009, the exit team of the Unit of Preventive Examinations, Tyumen Regional Clinical Hospital, examined 1120 male shift workers of the oil-field facilities of the Tyumen Region. RESULTS: The health of the examined shift workers was generally better than the national and regional indices. At the same time a number of observations demonstrated that shift work had a negative impact on the function of the viscera and UGS in the men, as evidenced by this clinical examination revealing arterial hypertension in 20 men and chronic bacterial prostatitis in 91. All patients with the newly identified diseases were registered to be followed up. In the extrashift period, they were successfully treated at the Diagnostic Center of the Tyumen Regional Hospital according to the national standards. CONCLUSION: The prophylactic medical examination of shift oil-field workers is substantiated by not only the compuIsory specialized examination for the early diagnosis of evolving diseases, but also by the fact that during their visits to specialists the men can really increase their awareness of their current health and the methods of its promotion.

[Urogenital diseases in men working "in shifts" in the oil fields of the Tyumen region].

Our study shows that urological health of men working in shifts in the oil fields of the Tyumen region is worse than mean national and regional characteristics. Newly diagnosed chronic bacterial prostatitis was prevalent among urogenital diseases. This situation can be explained by professional working and rest conditions for workers in the oil fields engaged in turn, by examination of the urologist participating in the health check-up team. Males with diagnosed prostatitis received treatment with the drug vitaprost plus produced in Russia with a good result.