Effects of poly- and monodisperse surfactants on 14C-epoxiconazole diffusion in isolated cuticles of Prunus laurocerasus.

BACKGROUND: Surfactants are known to enhance the foliar uptake of agrochemicals. It was the aim of this study to compare the enhancing effect of three polydisperse surfactants (Brij 30, Plurafac LF300 and Wettol LF700) and five monodisperse alcohol ethoxylates (C12 E3, C12 E4, C12 E5, C12 E6 and C12 E8) on (14)C-epoxiconazole diffusion in cuticles isolated from cherry laurel (Prunus laurocerasus L.). RESULTS: Rate constants (k*) of (14) C-epoxiconazole diffusion were measured in the presence and in the absence of the surfactants. Polydisperse surfactants increased the rates of foliar penetration of (14) C-epoxiconazole by factors of between 8 and 16. With monodisperse surfactants, enhancing effects on cuticular penetration were 2-16-fold. Effects were highest with alcohol ethoxylates of intermediate size, whereas they were lower for the smaller, more lipophilic and the larger, more polar monomers. In addition, diffusion of four monodisperse alcohol ethoxylates (C12 E3, C12 E4, C12 E5 and C12 E6 ) across cuticles was measured. Rate constants of alcohol ethoxylates decreased with decreasing lipophility and increasing molecular weight. CONCLUSION: The results indicate that enhancement of foliar penetration across cuticles by surfactants was most efficient when both (14)C-epoxiconazole and surfactants had similar mobilities in the transport-limiting barrier of the cuticles. This observation should be of interest in future strategies to optimise foliar uptake of agrochemicals using surfactants.

Highly concentrated emulsified microemulsions as solvent-free plant protection formulations.

Effective plant protection agents are readily available and well implemented in industry. However, delivery to the plant and application on the leaf are processes that still need to be optimized. Up to now plant protection formulations represent either emulsion or suspension concentrates that often contain environmentally harmful organic solvents and/or adjuvants. Emulsified microemulsions are hierarchically organized systems comprising emulsion droplets that confine a water-in-oil microemulsion. In the present contribution we show that emulsified microemulsions prepared from environmentally friendly components can be loaded with the plant-protection agent Fenpropimorph® up to 48 wt.% without organic solvent. The emulsion itself is highly concentrated, containing 60 wt.% of dispersed phase, and can be readily diluted with water for spraying in farming applications. Small-angle X-ray measurements reveal the existence of a water-in-Fenpropimorph® microemulsion confined inside the emulsion droplets. Dynamic light scattering shows that the emulsions prepared are monomodal, comprising droplet radii in the hundred nanometer range.