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Chemistry ; 28(13): e202103728, 2022 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-35076117

RESUMO

An electrochemical method for the green and practical synthesis of a broad range of substituted isoxazoline cores is presented. Both aryl and more challenging alkyl aldoximes are converted to the desired isoxazoline in an electrochemically enabled regio- and diastereoselective reaction with electron-deficient alkenes. Additionally, in-situ reaction monitoring methods compatible with electrochemistry equipment have been developed in order to probe the reaction pathway. Supporting analyses from kinetic (time-course) modelling and density functional theory support a stepwise, radical-mediated mechanism, and discounts hypothesised involvement of closed shell [3+2] cycloaddition pathways.


Assuntos
Alcenos , Isoxazóis , Reação de Cicloadição , Elétrons , Oximas
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