RESUMO
Aziridinylbenzoquinone (AZQ), Acridinyl Anisidide (m-AMSA), Tenipsode Thenvlidene-Lignan-(VM-26), and PCNU are relatively new synthetic drugs believed to have a wide spectrum of antitumor activity. Preparation of these drugs for administration requires reconstitution with an organic solvent which decomposes the thermoplastic components of I.V. infusion devices and chemo-dispensing pins. The products of this decomposition may lead to cellular damage and complicate the infusion of these agents.
Assuntos
Resinas Acrílicas , Butadienos , Interações Medicamentosas , Plásticos , Poliestirenos , Solventes/efeitos adversos , Acetamidas/efeitos adversos , Antineoplásicos/administração & dosagem , Injeções Intravenosas/instrumentaçãoRESUMO
The fixed cutaneous type of sporotrichosis is difficult to diagnose because clinical lesions are variable in appearance and the cells of Sporothrix schenckii are usually scarce in skin biopsy specimens. We have described two patients with lesions of fixed cutaneous sporotrichosis that resembled other inflammatory skin conditions and were treated with intralesional corticosteroids. Subsequent skin biopsies from these lesions demonstrated an unusually large number of yeast cells.
Assuntos
Dermatopatias Infecciosas/patologia , Esporotricose/patologia , Corticosteroides/uso terapêutico , Idoso , Biópsia , Criança , Feminino , Humanos , Terapia de Imunossupressão , Masculino , RecidivaRESUMO
Trichosporon beigelii fungemia and multiple, purpuric, papular skin lesions developed on the chest wall and extremities of a 22-year-old man with acute granulocytic leukemia. Histologically, the skin lesions demonstrated dermal budding yeasts, which were identified as T beigelii in culture. Unexplained biventricular, congestive heart failure and sepsis wit Streptococcus intermedius developed, and the patient died 28 days after his admission to the hospital.
Assuntos
Dermatomicoses/etiologia , Fungos Mitospóricos , Micoses/etiologia , Sepse/etiologia , Adulto , Dermatomicoses/patologia , Humanos , Leucemia Mieloide Aguda/complicações , Leucemia Mieloide Aguda/tratamento farmacológico , Masculino , Fungos Mitospóricos/isolamento & purificaçãoRESUMO
Cis-Platinum is a phase II chemotherapeutic agent effective against a variety of tumors. Known toxic effects include gastrointestinal, renal, audiologic, and hematologic as well as idiosyncratic and atopic. A 30-year-old male who was treated with cis-Platinum diamminedichloride II for disseminated embryonal cell carcinoma of the testicle developed seizures and cortical blindness.
