RESUMO
The composition, environmental fate, and effects of the polybrominated biphenyls (Firemaster BP-6 or FF-1) involved in the accidental contamination of cattle feed in Michigan in 1973 are reviewed. Toxic effects referred to in this report are limited to those occurring in domestic and laboratory animals and include general toxicity, neurobehavioral toxicity, immunotoxicity, reproductive toxicity, mutagenicity and carcinogenicity. The absorption, distribution, biotransformation and elimination of these polybrominated biphenyls are discussed along with the interactions with other chemicals and drugs.
Assuntos
Compostos de Bifenilo/toxicidade , Bifenil Polibromatos/toxicidade , Animais , Comportamento Animal/efeitos dos fármacos , Biotransformação , Carcinógenos , Fenômenos Químicos , Química , Galinhas , Poluição Ambiental/análise , Indução Enzimática/efeitos dos fármacos , Imunidade/efeitos dos fármacos , Absorção Intestinal , Mutagênicos , Bifenil Polibromatos/análise , Reprodução/efeitos dos fármacos , Ovinos , Suínos , Distribuição TecidualAssuntos
DNA/biossíntese , Células HeLa/metabolismo , Hidroxiureia/farmacologia , Alcanossulfonatos/farmacologia , Células Cultivadas , Centrifugação com Gradiente de Concentração , Clordano/farmacologia , Cicloexilaminas/farmacologia , DDT/farmacologia , Reparo do DNA/efeitos dos fármacos , Células HeLa/efeitos da radiação , Hidroxilaminas/farmacologia , Compostos de Metilmercúrio/farmacologia , Timidina/metabolismo , Trítio , Raios Ultravioleta/efeitos adversosAssuntos
Linfoma/enzimologia , Mutação , Timidina Quinase , Animais , Bromodesoxiuridina , Contagem de Células , Linhagem Celular , Células Clonais/enzimologia , Meios de Cultura , Resistência a Medicamentos , Etilaminas/farmacologia , Glicina , Hipoxantinas , Metano/farmacologia , Metanol/farmacologia , Metotrexato , Camundongos , Neoplasias Experimentais/enzimologia , Fenótipo , Radiogenética , Ácidos Sulfônicos/farmacologia , Timidina , Xantenos/farmacologiaRESUMO
Studies were conducted on two mutants of Escherichia coli that lack either glucosamine-6-phosphate deaminase or N-acetylglucosamine-6-phosphate deacetylase and which accumulate glucosamine-6-phosphate or N-acetylglucosamine-6-phosphate, respectively, when grown in the presence of N-acetylglucosamine. The addition of 10(-4) to 10(-5)mN-acetylglucosamine to these mutant strains caused a rapid and complete inhibition of growth on substrates that enter the catabolic pathways at or below the level of fructose-6-phosphate. Growth on glucose was inhibited to a lesser degree, whereas only minor inhibition occurred when the pentoses were used as substrates. Growth on gluconate was found to be totally unaffected by these levels of N-acetylglucosamine. The objective of this investigation was to determine the nature of this "amino sugar sensitivity" phenomenon and the conditions under which it could be overcome. It was found that this amino sugar sensitivity was abolished when an exogenous source of pentose such as uridine was included in the culture medium. Experiments are described indicating that the accumulated amino sugar phosphate metabolites interfere with an early step in hexose metabolism of both mutants, resulting in a pentose deficiency and consequent inhibition of growth on certain substrates.
