RESUMO
Twenty-one puerperal women were divided into two groups, those with high (4 L/day) and those with low (800 mL/day) fluid intake. Basal and post-suckling serum prolactin levels and the production rate of breast milk were similar in each group. Osmotic influences on prolactin secretion appear to be unimportant in human physiology, and there is no basis for prescribing changes in fluid intake for the control of human lactation.
PIP: A study was undertaken to test the effects of physiological variations in fluid intake on prolactin secretion and milk yield in the peurperium. 21 multiparous women were randomly assigned to a fluid-excess or a fluid-restricted group. Observations of urine osmolality and milk yield were made on the 4th, 5th, and 6th days postpartum. Urine output did rise in the fluid-excess group. However, milk yield was found to be similar in the 2 groups. Suckling caused a rise in the serum prolactin levels in both groups. Basal serum prolactin levels appeared to fall in the fluid-restricted group, but this finding is of doubtful significance. There is no basis, as a result of this study, to prescribe changes in fluid intake for the control of human lactation.
Assuntos
Lactação , Prolactina/sangue , Equilíbrio Hidroeletrolítico , Feminino , Humanos , Período Pós-Parto , GravidezRESUMO
Abnormal secretion of prolactin is amongst the many disorders of hormone secretion which have been proposed as potential causes for the common syndrome of premenstrual tension. Eight women suffering from this disorder participated in a five-month double-blind crossover trial of bromocriptine (5 mg per day) given in the luteal phase of the cycle. Significant improvement in most symptoms occurred during active as opposed to placebo therapy, together with objective evidence of a decrease in premenstrual weight gain and breast enlargement. This corresponds with the results of other studies which used bromocriptine in this dosage. The effect may be mediated by suppression of prolactin secretion, but could equally be a direct effect of bromocriptine.
Assuntos
Bromocriptina/uso terapêutico , Síndrome Pré-Menstrual/tratamento farmacológico , Prolactina/sangue , Adulto , Peso Corporal , Ensaios Clínicos como Assunto , Método Duplo-Cego , Feminino , Humanos , Pessoa de Meia-Idade , Síndrome Pré-Menstrual/sangue , Síndrome Pré-Menstrual/fisiopatologia , SíndromeRESUMO
In a consecutive group of 25 children with defective growth being evaluated for growth hormone deficiency, EEG-monitored slow-wave sleep provided discriminatory serum growth hormone responses equivalent to those obtained by arginine and insulin-hypoglycaemia provocation. Exercise was less effective but was able to provide a useful screening test. In 2 subjects with abnormal physiological but normal pharmacological serum growth hormone responses, therapeutic administration of growth hormone in one resulted in a significant growth increment, whereas in the other, advanced epiphyseal maturity precluded adequate evaluation. A normal growth hormone response to a pharmacological stimulus does not exclude a therapeutic response to human growth hormone.