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1.
Acta Biomed ; 94(S2): e2023091, 2023 06 23.
Artigo em Inglês | MEDLINE | ID: mdl-37366182

RESUMO

Talus dislocation is a rare injury and it is usually the consequence of high energy traumas, despite the anatomical features of the talus which predispose to its dissociation (absence of muscle insertions with over 60% of the surface covered by cartilage). It may be associated with malleolar fractures. Standard treatment of closed talar dislocation is a controversial issue. The most common early complications is avascular necrosis. Authors report a case of a complete talar dislocation associated to displaced lateral malleolar fracture in a 18-years-old male following a high energy trauma treated by closed reduction and fixation of the malleolar fracture.


Assuntos
Fraturas do Tornozelo , Fraturas Ósseas , Luxações Articulares , Osteonecrose , Tálus , Humanos , Masculino , Adolescente , Tálus/lesões , Fraturas do Tornozelo/diagnóstico por imagem , Fraturas do Tornozelo/etiologia , Fraturas do Tornozelo/cirurgia , Fraturas Ósseas/cirurgia , Luxações Articulares/diagnóstico por imagem , Luxações Articulares/etiologia , Luxações Articulares/cirurgia , Fixação Interna de Fraturas , Osteonecrose/complicações
3.
Aesthetic Plast Surg ; 44(6): 2051-2060, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32112193

RESUMO

BACKGROUND: Acellular dermal matrices have been introduced to optimize direct-to-implant breast reconstruction. We selected a bovine pericardium noncross-linked matrix. METHODS: The study consists in the retrospective analysis of 123 patients (141 breasts) who underwent conservative mastectomy and immediate implant-based breast reconstruction with bovine pericardium matrix Veritas® from March 2012 to October 2017. RESULTS: The overall rates of early and late complications, after a median follow-up of 51.84 months, were, respectively, 37.6% and 24.1%. The most noticeable early complications were flap ischemia [n = 39 (27.7%)], hematoma [n = 5 (3.6%)], marginal skin flap necrosis [n = 5 (3.6%)] and dehiscence of the surgical wound [n = 2 (1.4%)]. The most common late complications were rippling [n = 18 (12.7%)] and seroma [n = 4 (2.8%)]. The rate of clinically relevant capsular contracture was low: 12.1% (n = 17) presented grade II and only 2.1%% (n = 3) grade III. Implant substitution became necessary for five patients (3.6%). Early complications occurred more frequently in patients undergoing therapeutic mastectomy (p = 0.031). Patients undergoing preoperative radiotherapy more frequently developed late complications (p = 0.012). A clinically relevant capsular contracture (grade II-III) was found in higher average patients age (p = 0.0019). The left side developed less frequently late complications except for rippling (p = 0.002). Rippling occurred more frequently in patients who sustained a nipple skin-sparing mastectomy (p = 0.035). CONCLUSION: Our results further support the safety of Veritas® in immediate implant-based breast reconstruction. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .


Assuntos
Derme Acelular , Implante Mamário , Implantes de Mama , Neoplasias da Mama , Mamoplastia , Animais , Implante Mamário/efeitos adversos , Neoplasias da Mama/cirurgia , Bovinos , Seguimentos , Humanos , Mamoplastia/efeitos adversos , Mastectomia , Pericárdio , Estudos Retrospectivos , Resultado do Tratamento
4.
Vet Res Commun ; 37(2): 101-8, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23315207

RESUMO

Several studies of canine spontaneous mast cell tumours have described mutations in the c-kit proto-oncogene. These mutations produce a constitutively activated product and have been suggested to play a role in the malignant transformation of mast cells. We hypothesize that the selective tyrosine kinase inhibitor imatinib mesylate inhibits signal transduction and induces apoptosis when tested in cutaneous canine mast cell tumour samples positive for mutation in c-kit exon 11. Three-dimensional ex vivo cultures of canine grade II mast cell tumour treated with STI-571 at 48, 72, and 96 h and tested for signal transduction and apoptosis using appropriate assays were used. There was a progressive and significant increase in caspase-3 and TUNEL-positive mast cells compared to the untreated cultures. Additionally, a concurrent reduced expression of Ki67 and BCL-2 was observed. Furthermore, the treated cultures showed a marked reduction of Kit expression. Our results demonstrate that STI-571 induces Caspase-dependent apoptosis in a canine neoplastic mast cells possessing mutations in c-kit exon 11.


Assuntos
Apoptose/efeitos dos fármacos , Benzamidas/uso terapêutico , Doenças do Cão/tratamento farmacológico , Mastocitoma Cutâneo/veterinária , Mutação , Piperazinas/uso terapêutico , Proteínas Proto-Oncogênicas c-kit/genética , Pirimidinas/uso terapêutico , Animais , Antineoplásicos/uso terapêutico , Biópsia/veterinária , Caspase 3/metabolismo , Doenças do Cão/genética , Doenças do Cão/metabolismo , Doenças do Cão/patologia , Cães , Éxons , Mesilato de Imatinib , Imuno-Histoquímica/veterinária , Marcação In Situ das Extremidades Cortadas/veterinária , Antígeno Ki-67/metabolismo , Masculino , Mastócitos/efeitos dos fármacos , Mastócitos/patologia , Mastocitoma Cutâneo/tratamento farmacológico , Mastocitoma Cutâneo/metabolismo , Mastocitoma Cutâneo/patologia , Inibidores de Proteínas Quinases/uso terapêutico , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
5.
Vet Surg ; 34(1): 78-82, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-15720601

RESUMO

OBJECTIVE: To describe a novel technique for blepharoplasty to cover a tissue defect involving >/=50% of the lower eyelid. STUDY DESIGN: Prospective clinical study. ANIMALS: Five cats with lower eyelid squamous cell carcinoma (SCC). METHODS: En bloc resection of SCC by removing >/=50% of the lower lid with either the medial or lateral canthus was performed without other adjunctive treatment for SCC. The lid defect was reconstructed with a transposition skin flap derived from the frontal (medial defect) or temporal (lateral defect) region. The third eyelid was advanced laterally without dissection from its insertion; its outer conjunctival layer was removed, and the skin flap was sutured with single interrupted sutures dorsally over the nictitating membrane, ventrally to the cutaneous edge of the surgical wound and medially or laterally (depending on the canthus removed) to the skin of the remaining lower lid. RESULTS: Satisfactory cosmetic and functional results were achieved and the Schirmer tear tests were normal. In 2 cats, the skin flap needed monthly hair trimming to avoid corneal lesions. CONCLUSIONS: After en bloc resection of SCC involving >/=50% of the lower eyelid, reconstruction can be achieved by relocation of the third eyelid and use of a cutaneous transposition flap sutured to the scarified external surface of the third eyelid. Eyelid apposition and lacrimal function were preserved. CLINICAL RELEVANCE: Blepharoplasty using a cutaneous transposition flap sutured to the scarified surface of a relocated third eyelid should be considered for reconstruction of lower eyelid defects with >/=50% tissue loss of the lid margin.


Assuntos
Blefaroplastia/veterinária , Carcinoma de Células Escamosas/veterinária , Doenças do Gato/cirurgia , Neoplasias Palpebrais/veterinária , Membrana Nictitante/cirurgia , Animais , Blefaroplastia/métodos , Carcinoma de Células Escamosas/cirurgia , Gatos , Neoplasias Palpebrais/cirurgia , Feminino , Masculino , Estudos Prospectivos , Retalhos Cirúrgicos/veterinária , Resultado do Tratamento
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