RESUMO
On the basis of previous personal data regarding glycidic, lipidic and protein metabolism in groups of young-old-cirrhotic and hypoglycaemic subjects, a correlative study has been carried out for the purpose of highlighting dependence situations between reduced cerebral activity in the elderly and liver-dependent metabolic changes. Specifically as regards protein metabolism, it is shown that all amino acids dependent on the senescence process (glutammic acid, cystine, thyrosine, histidine, threonine, serine) are related to those involved in altered consciousness states (hepatic and hypoglycaemic coma). It is thus possible that in the elderly too there may be some correlation between liver function deficiency and senile encephalopathy.
Assuntos
Aminoácidos/metabolismo , Encéfalo/metabolismo , Fígado/metabolismo , Idoso , Envelhecimento , Cistina/metabolismo , Glutamatos/metabolismo , Histidina/metabolismo , Humanos , Serina/metabolismo , Treonina/metabolismo , Tirosina/metabolismoRESUMO
Analysis of the discriminating function was applied to 15 plasma lipid parameters: palmitic, palmitoleic, stearic, oleic and linoleic acids, total NEFA, total lipids, triglycerides, phospholipids, total cholesterol, alpha and beta lipoproteic cholesterol, and lipoproteic alpha: beta, cholesterol: triglycerides and cholesterol: phospholipids ratios, in 84 healthy, normosomic subjects, divided into young, presenile and aged. Highly significant discrimination was obtained between all three groups. The coefficients of discrimination of all the variables employed in individual comparisons are illustrated. A brief account is given of the importance of biohumoral data in the detection of aging, and of the theoretical and practical utility of an investigation of this kind.
Assuntos
Lipídeos/sangue , Adulto , Fatores Etários , Idoso , Colesterol/sangue , Ácidos Graxos não Esterificados/sangue , Feminino , Humanos , Ácidos Linoleicos/sangue , Lipoproteínas/sangue , Masculino , Pessoa de Meia-Idade , Ácidos Palmíticos/sangue , Valores de Referência , Triglicerídeos/sangueRESUMO
Changes in intermediate metabolism (amino acids, carbohydrates and plasma NEFA) noted in diabetes, obesity and old age are discussed. Results obtained in a series of 1200 cases treated with sulphanylurea with or without biguanides are presented. Metabolic compensation was obtained with the association in a larger number of obese and aged diabetics (about 15%).
