Long-term consequences of primary percutaneous coronary intervention in patients with st-elevation myocardial infarction.

OBJECTIVE: The aim: To investigate long-term effects of primary percutaneous coronary interventions (pPCI) in patients with STEMI basing on the prevalence of clinically relevant endpoints. PATIENTS AND METHODS: Materials and methods: Totally 200 patients with STEMI hospitalized within a period of "therapeutic window" for revascularization were included into the study. 100 patients who additionally to pPCI underwent manual thromboaspiration entered the main group. The comparison group consisted of 100 patients who underwent standard pPCI. RESULTS: Results: Six months after the pPCI, the incidence of either major adverse cardiac events and the combined endpoint did not differ in the main and comparative groups (11.8% vs. 12.5%, p = 0.888 and 18.2% vs. 20.8%, p = 0.658, respectively). There were no significant differences in these endpoints taken separately. In twelve months after procedure, also there were no significant differences between the groups. However, a tendency toward lower incidence of chest pain was observed in the main group (p = 0.08) during this period that was lost in 24 months after pPCI. None of these techniques demonstrated significant advantages during the whole duration of the follow-up period. CONCLUSION: Conclusions: The addition of manual thromboaspiration to the standard pPCI in patients with STEMI and severe thrombosis of the culprit artery did not significantly influence the prognosis.

Chronic heart failure course prognosis depending on body weight and endogenous intoxication syndrome.

OBJECTIVE: Introduction: Over the years, heart failure remains one of the most common and prognostically unfavorable conditions. The aim of our study was to determine the frequency of complications in patients with CHF depending on the body weight and intoxication syndrome of varying degrees of severity. PATIENTS AND METHODS: Materials and methods: A complete clinical examination was performed in 58 patients (41 (70.6%) men and 17 (29.4%) women) with CHF. In addition to the standard examination in accordance with the protocol, the level of endogenous intoxication was determined by the level of medium-weight molecules (MWM254) and leptin. The patients were randomized into 4 groups depending on their body mass index and the degree of endogenous intoxication. Statistical processing of the results was carried out using the methods of variation statistics "Statistica 6.0". RESULTS: Results: It was revealed that the worst survival rate is observed in patients with normal body mass against the background of the expressed endogenous intoxication syndrome, the best survival rate is observed provided that there are a normal body mass and endogenous intoxication of a minimum degree. An inverse correlation between the body mass index and the endogenous intoxication indicator (blood MWM) was detected. Patients with CHF should have their leptin level evaluated. An increase in its level was associated with arterial hypertension, an increase in blood glucose levels and lipid metabolism disorders. CONCLUSION: Conclusions: Increased level of blood MWM worsens the forecast of CHF. The unfavorable outcome was observed in patients with the combination of hypoleptinemia with severe endogenous intoxication.

ASIT therapy: advantages and adverse effects. own results and literature data.

OBJECTIVE: Introduction: Allergy is an important medical, social and economic problem nowadays, as it causes disability and patients' quality of life decreases. According to the update data all the existing therapeutic options haven't been used in huge majority of patients. Allergen-specific immunotherapy (ASIT) underuse in particular. One of the reasons for the low frequency of this treatment method using is the fear of systemic and local allergic. The aim of the study was to find out the incidence and severity of adverse reactions in patients receiving subcutaneous and sublingual ASIT. PATIENTS AND METHODS: Materials and methods: In conducted research we compared peculiarities of adverse reactions using sublingual and subcutaneous ASIT methods. Criteria for inclusion in the research were age from 18 to 50 years, diagnosed intermittent or persistent BA. The investigation involved 51 patients with combined basic drug therapy and ASIT, which was performed with injected allergens for 38 patients and sublingual allergens - for 13 individuals. RESULTS: Results: Local reactions were recorded in five patients (13.16%), who received injected ASIT. In four patients (10.52%), dry rales were observed for a short period after injection of the allergen. Local side effect was observed in one patient (7.69%) during sublingual ASIT. CONCLUSION: Conclusions: Adverse reactions, that occur during ASIT, do not pose a threat to patients' lives. However, the therapeutic effect after the year of treatment was significantly better than in patients who used medications only. Modern drugs are safe and, if all the rules are followed, the risk of adverse effects is very low.

The influence of the manual thrombus aspiration on the short term effectiveness of the percutaneous revascularization in patients with coronary artery thrombosis.

OBJECTIVE: Introduction: Percutaneous coronary intervention (PCI) is one of the main issues in treatment of acute coronary syndrome with ST segment elevation (STEMI). The manual thrombus aspiration was believed to improve the results of intervention especially in patients with coronary thrombosis. The aim: To explore the influence of manual thrombus aspiration on the short-termed prognosis after PCI in patients with STEMI and visible coronary thrombosis. PATIENTS AND METHODS: Materials and methods: 50 patients with STEMI and visible coronary thrombosis were included for exploration. Main group (MG) consists of 25 patients to whom manual thrombus aspiration was performed and comparison group (CG) of 25 patients whom were performed just conventional PCI. RESULTS: Results: In the 84% patients of the MG and in 72% CG was gained ТІМІ 3 flow grade after the procedure (р=0.5). MBG 3 was reached in similar number of patients from both groups ( р=0.37). Comparison of the ejection fraction of the LV and its' wall motion score brought the same results. The trend to better indexes of glomerular filtration rate was observed in the patients of the MG (р=0.18). Need of the balloon angioplasty before stenting was the unique index improved by the manual thrombus aspiration (р=0.02). CONCLUSION: Conclisions: No significant advantages of the manual thrombus aspiration usage weren't revealed compearing to conventional PCI in our study in the patients with STEMI and visible coronary thrombosis. At the same time few insignificant trends were reveled. So the more powerful trial is needed to solve this problem.